概述

  • 产品名称Anti-RMI2抗体
    参阅全部 RMI2 一抗
  • 描述
    兔多克隆抗体to RMI2
  • 经测试应用适用于: ICC/IF, WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence: GKYVMVMGVV QACSPEPCLQ AVKMTDLSDN PIHESMWELE VEDLHRNI, corresponding to amino acids 99-146 of Human RMI2.

  • 阳性对照
    • Human stomach tissue; RT 4, U 251 MG and Human liver lysates; U 251 MG cells.

性能

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应用

Our Abpromise guarantee covers the use of ab122685 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 1 - 4 µg/ml. using PFA/Triton X-100 Fixation/Permeabilization.
WB 1/250 - 1/500.
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. The complex is therefore essential for the stability, localization, and function of complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.
  • 序列相似性Belongs to the RMI2 family.
    Contains 1 OB DNA-binding domain.
  • 翻译后修饰Phosphorylated during mitosis.
  • 细胞定位Nucleus. Colocalizes with BLM at nuclear DNA repair foci.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BLAP18 antibody
    • BLM-associated protein of 18 kDa antibody
    • C16orf75 antibody
    • hRMI2 antibody
    • MGC24665 antibody
    • RecQ-mediated genome instability protein 2 antibody
    • RMI2 antibody
    • RMI2_HUMAN antibody
    see all

Anti-RMI2 antibody 图像

  • ab122685, at 1/200 dilution, staining RMI2 in paraffin-embedded Human stomach tissue by Immunohistochemistry.
  • ab122685, at 4 µg/ml staining RIM2 in PFA/Triton X-100 fixed/permeabilized U 251 MG cells by Immunofluorescence (green).
  • All lanes : Anti-RMI2 antibody (ab122685) at 1/250 dilution

    Lane 1 : RT 4 lysate
    Lane 2 : U 251 MG lysate
    Lane 3 : Human plasma lysate
    Lane 4 : Human liver lysate
    Lane 5 : Human tonsil lysate

Anti-RMI2 antibody (ab122685)参考文献

ab122685 has not yet been referenced specifically in any publications.

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