Mouse, Rat, Human
, corresponding to amino acids 11/30 of Human RIP2.
(Peptide available as
A431 or K562 whole cell lysate
An approximately60 kDa band can be detected.
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000. Detects a band of approximately 60 kDa.Can be blocked with
Human RIP2 peptide (ab8463).
Use a concentration of 10 µg/ml.
Activates pro-caspase-1 and pro-caspase-8. Potentiates CASP8-mediated apoptosis. Activates NF-kappa-B.
Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Contains 1 CARD domain. Contains 1 protein kinase domain.
Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.
Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination catalyzed by ITCH.
Information by UniProt
CARD 3 antibody
CARD carrying kinase antibody
CARD containing ICE associated kinase antibody
Anti-RIP2 antibody (ab8428)参考文献
This product has been referenced in:
et al. Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling. Biochem Biophys Res Commun 474:452-461 (2016).
Read more (PubMed: 27133719) »
et al. Inhibition of RICK/nuclear factor-kappaB and p38 signaling attenuates the inflammatory response in a murine model of Crohn disease. J Biol Chem 280:14981-8 (2005).
Read more (PubMed: 15691843) »
See all 2 Publications
for this product
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"