Mouse, Rat, Human
, corresponding to amino acids 508-522 of Human RIP2.
(Peptide available as
K562 or 3T3 whole celllysate
An approximately60 kDa band can be detected.
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500. Detects a band of approximately 60 kDa.Can be blocked with
Human RIP2 peptide (ab8462).
Use a concentration of 5 µg/ml.
Activates pro-caspase-1 and pro-caspase-8. Potentiates CASP8-mediated apoptosis. Activates NF-kappa-B.
Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Contains 1 CARD domain. Contains 1 protein kinase domain.
Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.
Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination catalyzed by ITCH.
Information by UniProt
CARD 3 antibody
CARD carrying kinase antibody
CARD containing ICE associated kinase antibody
Anti-RIP2 antibody (ab8427)参考文献
This product has been referenced in:
et al. Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-?B signaling. J Immunol 192:4379-85 (2014).
Read more (PubMed: 24706726) »
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"