Anti-RIP140抗体[2656C6a] (ab53740)

概述

  • 产品名称Anti-RIP140抗体[2656C6a]
    参阅全部 RIP140 一抗
  • 描述
    小鼠单克隆抗体[2656C6a] to RIP140
  • 经测试应用适用于: WB, Dot blotmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment (Human)

性能

应用

Our Abpromise guarantee covers the use of ab53740 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 129 kDa.
Dot blot Use at an assay dependent dilution.

靶标

  • 功能Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors.
  • 结构域Contains 9 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which have different affinities for nuclear receptors. The C-terminal LTKTNPILYYMLQK motif is required for ligand-dependent interaction with RAAR and RXRB homodimers and heterodimers, for the corepressor activity, and for the formation of an HDAC3 complex with RARA/RXRB (By similarity). Contains at least four autonomous repression domains (RD1-4). RD1 functions via a histone deacetylase (HDAC)-independent mechanism, whereas RD2, RD3 and RD4 can function by HDAC-dependent or independent mechanisms, depending on cell type. RD2 is dependent on CTBP binding.
  • 翻译后修饰Acetylation regulates its nuclear translocation and corepressive activity (By similarity). Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH.
  • 细胞定位Nucleus. Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand-bound NR3C1.
  • Information by UniProt
  • 数据库链接
  • 别名
    • NRIP 1 antibody
    • NRIP1 antibody
    • NRIP1_HUMAN antibody
    • Nuclear factor RIP 140 antibody
    • Nuclear factor RIP140 antibody
    • Nuclear receptor interacting protein 1 antibody
    • Nuclear receptor-interacting protein 1 antibody
    • Receptor interacting protein 140 antibody
    • Receptor-interacting protein 140 antibody
    • RIP 140 antibody
    • RIP140 antibody
    see all

Anti-RIP140 antibody [2656C6a] 图像

Anti-RIP140 antibody [2656C6a] (ab53740)参考文献

ab53740 has not yet been referenced specifically in any publications.

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