概述

  • 产品名称Rif1肽(2076-2089)

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-EEGIIDANKTETNT
    • 氨基酸2076 to 2089

技术指标

Our Abpromise guarantee covers the use of ab45640 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • DKFZp781N1478
    • FLJ10599
    • FLJ11269
    • FLJ12870
    • Rap1 interacting factor 1
    • Rap1 interacting factor 1 homolog
    • RAP1 interacting factor homolog
    • RAP1 interacting factor homolog (yeast)
    • Rap1-interacting factor 1 homolog
    • Receptor interacting factor 1
    • RIF 1
    • RIF1
    • RIF1 isoform 4
    • RIF1_HUMAN
    • Telomere associated protein RIF 1
    • Telomere associated protein RIF1
    • Telomere-associated protein RIF1
    • Telomeric protein RIF 1
    • Telomeric protein RIF1
    see all
  • 功能Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S-phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints.
  • 组织特异性Highly expressed in testis.
  • 发展阶段Expression peaks in late G2/S phase of the cell cycle.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus. Chromosome > telomere. Cytoplasm > cytoskeleton > spindle. Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs). Does not associate with normal telomere structures. Localizes to microtubules of the midzone of the mitotic spindle during anaphase, and to condensed chromosomes in telophase.
  • Information by UniProt

Rif1 peptide (2076-2089) (ab45640)参考文献

ab45640 has not yet been referenced specifically in any publications.

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