概述

  • 产品名称Anti-Rif1抗体
    参阅全部 Rif1 一抗
  • 描述
    兔多克隆抗体to Rif1
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region between residues 2425 and the C-terminus (residue 2472) of Human Rif1 (NP_060621.3).

  • 阳性对照
    • Human seminoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab84785 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S-phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints.
    • 组织特异性Highly expressed in testis.
    • 发展阶段Expression peaks in late G2/S phase of the cell cycle.
    • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Nucleus. Chromosome > telomere. Cytoplasm > cytoskeleton > spindle. Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs). Does not associate with normal telomere structures. Localizes to microtubules of the midzone of the mitotic spindle during anaphase, and to condensed chromosomes in telophase.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DKFZp781N1478 antibody
      • FLJ10599 antibody
      • FLJ11269 antibody
      • FLJ12870 antibody
      • Rap1 interacting factor 1 antibody
      • Rap1 interacting factor 1 homolog antibody
      • RAP1 interacting factor homolog antibody
      • RAP1 interacting factor homolog (yeast) antibody
      • Rap1-interacting factor 1 homolog antibody
      • Receptor interacting factor 1 antibody
      • RIF 1 antibody
      • RIF1 antibody
      • RIF1 isoform 4 antibody
      • RIF1_HUMAN antibody
      • Telomere associated protein RIF 1 antibody
      • Telomere associated protein RIF1 antibody
      • Telomere-associated protein RIF1 antibody
      • Telomeric protein RIF 1 antibody
      • Telomeric protein RIF1 antibody
      see all

    Anti-Rif1 antibody 图像

    • ab84785, at 1/250 dilution, staining Rif1 in formalin-fixed, paraffin-embedded human seminoma by Immunohistochemistry using DAB staining.

    Anti-Rif1 antibody (ab84785)参考文献

    ab84785 has not yet been referenced specifically in any publications.

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