概述

  • 产品名称Anti-RICTOR抗体
    参阅全部 RICTOR 一抗
  • 描述
    兔多克隆抗体to RICTOR
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    KLH conjugated synthetic peptide selected from the C terminal region of human RICTOR.

  • 阳性对照
    • Human testis tissue

性能

应用

Our Abpromise guarantee covers the use of ab79984 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
IHC-P
  • 应用说明ELISA: 1/1000.
    IHC-P: 1/10 - 1/50.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
    • 序列相似性Belongs to the RICTOR family.
    • 翻译后修饰Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AVO3 antibody
      • AVO3 homolog antibody
      • DKFZp686B11164 antibody
      • hAVO3 antibody
      • KIAA1999 antibody
      • Likely ortholog of mouse TORC2 specific protein AVO3 (S. cerevisiae) antibody
      • mAVO3 antibody
      • MGC39830 antibody
      • PIA antibody
      • Pianissimo antibody
      • Rapamycin insensitive companion of mTOR antibody
      • Rapamycin-insensitive companion of mTOR antibody
      • Rictor antibody
      • RICTR antibody
      • RICTR_HUMAN antibody
      • RPTOR independent companion of MTOR complex 2 antibody
      • TORC2 specific protein AVO3 antibody
      see all

    Anti-RICTOR antibody 图像

    • ab79984, at a 1/10 dilution, staining RICTOR in formalin fixed, paraffin embedded human testis tissue by Immunohistochemistry. ab79984 was peroxidase conjugated to the secondary antibody, followed by DAB staining.

    Anti-RICTOR antibody (ab79984)参考文献

    ab79984 has not yet been referenced specifically in any publications.

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