概述

  • 产品名称Anti-RGS9抗体
    参阅全部 RGS9 一抗
  • 描述
    兔多克隆抗体to RGS9
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Horse, Guinea pig, Cat
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 624-673 of Human RGS9 (NP_003826)

  • 阳性对照
    • Human fetal spleen lysate

性能

应用

Our Abpromise guarantee covers the use of ab97702 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 77 kDa. Optimal concentration of antibody depends the protein level in a given sample. Our recommended concentrations are the starting point for general use. Customers are advised have to do a series of titration tests to determine optimal concentration. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(t)-alpha. Involved in phototransduction; key element in the recovery phase of visual transduction.
  • 组织特异性Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors).
  • 疾病相关Defects in RGS9 are a cause of prolonged electroretinal response suppression (PERRS) [MIM:608415]; also known as bradyopsia. PERRS is characterized by difficulty adjusting to sudden changes in luminance levels mediated by cones.
  • 序列相似性Contains 1 DEP domain.
    Contains 1 G protein gamma domain.
    Contains 1 RGS domain.
  • 结构域In photoreceptor cells the DEP domain is essential for targeting RGS9 to the outer rod segments.
  • 翻译后修饰Retinal isoform 3 is light-dependent phosphorylated at 'Ser-478'. Phosphorylation is decreased by light exposition.
  • 细胞定位Membrane. Isoform 3 is targeted to the membrane via its interaction with RGS9BP.
  • Information by UniProt
  • 数据库链接
  • 别名
    • PERRS antibody
    • R9AP antibody
    • Regulator of G protein signalling 9 antibody
    • Regulator of G-protein signaling 9 antibody
    • RGS9 antibody
    • RGS9_HUMAN antibody
    • RGS9L antibody
    see all

Anti-RGS9 antibody 图像

  • Anti-RGS9 antibody (ab97702) at 1 µg/ml (in 5% skim milk / PBS buffer) + human fetal spleen lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 77 kDa

Anti-RGS9 antibody (ab97702)参考文献

ab97702 has not yet been referenced specifically in any publications.

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