概述

  • 产品名称Anti-RGS4抗体
    参阅全部 RGS4 一抗
  • 描述
    兔多克隆抗体to RGS4
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Guinea pig, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within C terminal amino acids 253-302 (IFNLMEKDSY RRFLKSRFYL DLVNPSSCGA EKQKGAKSSA DCASLVPQCA) of Human RGS4 (NP_001095915).

  • 阳性对照
    • HepG2 cell lysate.

性能

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应用

Our Abpromise guarantee covers the use of ab125333 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 34 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
  • 疾病相关Genetic variation in RGS4 is associated with susceptibility to schizophrenia type 9 (SCZD9) [MIM:604906]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
  • 序列相似性Contains 1 RGS domain.
  • 翻译后修饰Palmitoylated on Cys-2 and/or Cys-12.
    Phosphorylated by cyclic GMP-dependent protein kinase.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MGC2124 antibody
    • MGC60244 antibody
    • Regulator of G protein signalling 4 antibody
    • Regulator of G-protein signaling 4 antibody
    • RGP 4 antibody
    • RGP4 antibody
    • RGS 4 antibody
    • RGS4 antibody
    • RGS4_HUMAN antibody
    • Schizophrenia disorder 9 antibody
    • SCZD 9 antibody
    • SCZD9 antibody
    see all

Anti-RGS4 antibody 图像

  • Anti-RGS4 antibody (ab125333) at 1 µg/ml + HepG2 cell lysate at 10 µg

    Predicted band size : 34 kDa

Anti-RGS4 antibody (ab125333)参考文献

ab125333 has not yet been referenced specifically in any publications.

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