Anti-RGS4抗体[2D3.3] (ab9962)

概述

  • 产品名称Anti-RGS4抗体[2D3.3]
    参阅全部 RGS4 一抗
  • 描述
    亚美尼亚仓鼠单克隆抗体[2D3.3] to RGS4
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Purified recombinant 6X His-tagged full length human RGS4 protein.

  • 表位N-terminus 22 aa.
  • 常规说明This antibody was raised in Armenian Hamster.

性能

应用

Our Abpromise guarantee covers the use of ab9962 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明Western blot: 1/500 block with 3% BSA, 1% non-fat dry milk in TBS-0.1% Tween (Whatman filtered).
  • 靶标

    • 功能Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
    • 疾病相关Genetic variation in RGS4 is associated with susceptibility to schizophrenia type 9 (SCZD9) [MIM:604906]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
    • 序列相似性Contains 1 RGS domain.
    • 翻译后修饰Palmitoylated on Cys-2 and/or Cys-12.
      Phosphorylated by cyclic GMP-dependent protein kinase.
    • Information by UniProt
    • 数据库链接
    • 别名
      • MGC2124 antibody
      • MGC60244 antibody
      • Regulator of G protein signalling 4 antibody
      • Regulator of G-protein signaling 4 antibody
      • RGP 4 antibody
      • RGP4 antibody
      • RGS 4 antibody
      • RGS4 antibody
      • RGS4_HUMAN antibody
      • Schizophrenia disorder 9 antibody
      • SCZD 9 antibody
      • SCZD9 antibody
      see all

    Anti-RGS4 antibody [2D3.3] (ab9962)参考文献

    ab9962 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for your patience, I have only just heard back from the antibody's originator. Ab9962 was raised in an Armenian hamster and will detect a band at 26 kDa. If you have any more questions, please contact us again.

    Thank you for your patience, I have only just heard back from the antibody's originator. Ab9962 was raised in an Armenian hamster. If you have any more questions, please contact us again.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"