概述

  • 产品名称
    Anti-RGS19抗体
  • 描述
    兔多克隆抗体to RGS19
  • 经测试应用
    适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, Cow
  • 免疫原

    Synthetic peptide within Human RGS19 aa 136-166 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary. Surrounding Serine 151.
    Database link: P49795

  • 阳性对照
    • Mouse muscle tissue lysate, Human lung carcinoma tissue.

应用

Our Abpromise guarantee covers the use of ab173878 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/50 - 1/100. Predicted molecular weight: 25 kDa.
IHC-P 1/10 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能
    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
  • 组织特异性
    Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
  • 序列相似性
    Contains 1 RGS domain.
  • 翻译后修饰
    Fatty acylated. Heavily palmitoylated in the cysteine string motif.
    Phosphorylated, mainly on serine residues.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • G alpha interacting protein antibody
    • G protein signalling regulator 19 antibody
    • G protein, alpha-interacting protein antibody
    • G-alpha-interacting protein antibody
    • GAIP antibody
    • GNAI3IP antibody
    • Guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein antibody
    • Regulator of G protein signalling 19 antibody
    • Regulator of G-protein signaling 19 antibody
    • RGS19 antibody
    • RGS19_HUMAN antibody
    • RGSGAIP antibody
    see all

图片

  • Anti-RGS19 antibody (ab173878) at 1/100 dilution + Mouse muscle tissue lysate at 35 µg

    Predicted band size : 25 kDa
  • Immunohistochemical analysis of paraffin embedded Human lung carcinoma tissue labeling RGS19 with ab173878 at 1/10 followed by peroxidase conjugation of the secondary antibody and DAB staining.

文献

ab173878 has not yet been referenced specifically in any publications.

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