• 产品名称Anti-RFXANK抗体
    参阅全部 RFXANK 一抗
  • 描述
    兔多克隆抗体to RFXANK
  • 经测试应用适用于: IP, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Cow, Dog, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Elephant
  • 免疫原

    Synthetic peptide (Human) conjugated to KLH - which represents aportion within the last 100 amino acids of the human Regulatory Factor X, Ankyrin Repeat-Containing (GenBank PID 4506499).


  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.1% Sodium Azide
    Constituents: 8mM PBS, 60mM Citrate, 150mM Tris, pH 7-8
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Antibodies were affinity purified using the peptide immobilized on solid support. Antibody concentration was determined by extinction coefficient: absorbance at 280 nmof 1.4 equals 1.0 mg of IgG.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域


Our Abpromise guarantee covers the use of ab9257 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明IP: Use at a concentration of 1 - 4 µl.
    WB: 1/500 - 1/5000.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. Isoform RFX-B-delta5 is not involved in the positive regulation of MHC class II genes.
    • 组织特异性Ubiquitous.
    • 疾病相关Defects in RFXANK are a cause of bare lymphocyte syndrome type 2 (BLS2) [MIM:209920]; also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.
    • 序列相似性Contains 5 ANK repeats.
    • 结构域The third ankyrin repeat is required for association with the two other RFX subunits; RFX5 and RFXAP.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ANKRA1 antibody
      • Ankyrin repeat containing regulatory factor X associated protein antibody
      • Ankyrin repeat family A protein 1 antibody
      • BLS antibody
      • DNA-binding protein RFXANK antibody
      • F14150_1 antibody
      • MGC138628 antibody
      • Regulatory factor X associated ankyrin containing protein antibody
      • Regulatory factor X subunit B antibody
      • Regulatory factor X, ankyrin repeat containing antibody
      • Regulatory factor X-associated ankyrin-containing protein antibody
      • RFX Bdelta4 antibody
      • RFX-B antibody
      • RFXANK antibody
      • RFXB antibody
      • RFXB delta 4 antibody
      • RFXK_HUMAN antibody
      see all

    Anti-RFXANK antibody (ab9257)参考文献

    ab9257 has not yet been referenced specifically in any publications.

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    Thank you for taking the time to complete our questionnaire. I am sorry to hear you have had difficulty obtaining satisfactory results from this antibody. The details you have kindly provided will enable us to investigate this case for you and this...

    Read More
    Abcam guarantees this product to work in the species/application used in this Abreview.
    Application Western blot
    Sample Human Cell lysate - nuclear (HCT116, Raji)
    Loading amount 50 µg
    Specification HCT116, Raji
    Gel Running Conditions Reduced Denaturing
    Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 20°C

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    提交于 Jan 08 2008