概述

  • 产品名称Anti-RFXANK抗体
    参阅全部 RFXANK 一抗
  • 描述
    兔多克隆抗体to RFXANK
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 93-123 of Human RFXANK (NP_604389.1, NP_003712.1).

  • 阳性对照
    • WiDr cell line lysates

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab124068 is purified through a protein A column, followed by peptide affinity purification.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab124068 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 28 kDa.

靶标

  • 功能Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. Isoform RFX-B-delta5 is not involved in the positive regulation of MHC class II genes.
  • 组织特异性Ubiquitous.
  • 疾病相关Defects in RFXANK are a cause of bare lymphocyte syndrome type 2 (BLS2) [MIM:209920]; also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.
  • 序列相似性Contains 5 ANK repeats.
  • 结构域The third ankyrin repeat is required for association with the two other RFX subunits; RFX5 and RFXAP.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ANKRA1 antibody
    • Ankyrin repeat containing regulatory factor X associated protein antibody
    • Ankyrin repeat family A protein 1 antibody
    • BLS antibody
    • DNA-binding protein RFXANK antibody
    • F14150_1 antibody
    • MGC138628 antibody
    • Regulatory factor X associated ankyrin containing protein antibody
    • Regulatory factor X subunit B antibody
    • Regulatory factor X, ankyrin repeat containing antibody
    • Regulatory factor X-associated ankyrin-containing protein antibody
    • RFX Bdelta4 antibody
    • RFX-B antibody
    • RFXANK antibody
    • RFXB antibody
    • RFXB delta 4 antibody
    • RFXK_HUMAN antibody
    see all

Anti-RFXANK antibody 图像

  • Anti-RFXANK antibody (ab124068) at 1/100 dilution + WiDr cell line lysates at 35 µg

    Predicted band size : 28 kDa

Anti-RFXANK antibody (ab124068)参考文献

ab124068 has not yet been referenced specifically in any publications.

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