Anti-REV3L抗体(ab111729)
Key features and details
- Rabbit polyclonal to REV3L
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-REV3L抗体 -
描述
兔多克隆抗体to REV3L -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse -
免疫原
Synthetic peptide corresponding to Human REV3L aa 200-300 (internal sequence).
Database link: O60673 -
阳性对照
- Human brain tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
PBS (without Mg2+ and Ca2+) -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
ab111729 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab111729于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P |
1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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说明 |
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IHC-P
1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis. -
组织特异性
Ubiquitously expressed. -
序列相似性
Belongs to the DNA polymerase type-B family.
Contains 1 CysA-type zinc finger. -
结构域
Its C-terminal part could serve as the catalytic domain during nucleotide polymerization, while its N-terminal part could provide sites for protein-protein interactions with other factors during translesion DNA synthesis.
The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 5980 Human
- Entrez Gene: 19714 Mouse
- Omim: 602776 Human
- SwissProt: O60673 Human
- SwissProt: Q61493 Mouse
- Unigene: 232021 Human
- Unigene: 439723 Mouse
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别名
- Catalytic subunit of DNA polymerase zeta antibody
- DNA polymerase zeta catalytic subunit antibody
- DPOLZ_HUMAN antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab111729 被引用在 1 文献中.
- Wang D et al. Lnc-PICSAR contributes to cisplatin resistance by miR-485-5p/REV3L axis in cutaneous squamous cell carcinoma. Open Life Sci 15:488-500 (2020). PubMed: 33817237