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The tumor microenvironment (TME) is the ecosystem of cells, blood vessels, and the extracellular matrix (ECM) surrounding a cancerous lesion that mediates key processes for the tumor. As a tumor constantly interacts with the TME, understanding this environment is vital in developing future therapeutics and diagnostic tools in immuno-oncology.
Multiplex imaging techniques are becoming increasingly popular to examine the complexities of the TME, overcoming traditional limitations in IHC. Also known as multiple immunolabeling or multiplex immunostaining, multiplex imaging enables study of expression patterns of different targets and the cell:cell interactions between immune, cancer, and stromal cells.
Learn more about the microenvironment during vascularization, growth, and metastasis through the interplay of tumor, stromal cells, and the immune system.
Get the full picture in your tumor microenvironment research with the best products and tools to support your research.
Explore the wide variety of antibody-based methods for multiplex tissue imaging and the key considerations for each.
Download this application note for abcam’s in-house experts plus Dr. Kosei Chan and Dr. Joe Gray’s experiences with tyramide signal amplification systems (TSA).
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