Anti-RERE抗体(ab103462)

概述

  • 产品名称Anti-RERE抗体
    参阅全部 RERE 一抗
  • 描述
    兔多克隆抗体to RERE
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    KLH conjugated synthetic peptide corresponding to a region within amino acids 389-418 from the N terminal region of Human RERE.

  • 阳性对照
    • Neuro-2a cell line lysates; lung carcinoma tissue

性能

应用

Our Abpromise guarantee covers the use of ab103462 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 172 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.
  • 组织特异性Widely expressed. Expressed in tumor cell lines.
  • 疾病相关Note=A chromosomal aberration involving RERE is found in the neuroblastoma cell line. Translocation t(1;15)(p36.2;q24).
  • 序列相似性Contains 1 BAH domain.
    Contains 1 ELM2 domain.
    Contains 1 GATA-type zinc finger.
    Contains 1 SANT domain.
  • 结构域The interaction with ATN1 is mediated by the coiled coil domain.
  • 细胞定位Nucleus. Localized in nuclear bodies of variables size. Colocalized with PML and BAX in nuclear PODs.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 1110033A15Rik antibody
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    • arginine glutamic acid dipeptide repeats antibody
    • Arginine glutamic acid dipeptide repeats protein antibody
    • Arginine-glutamic acid dipeptide repeats protein antibody
    • ARGININE-GLUTAMIC ACID REPEATS-ENCODING GENE antibody
    • ARP antibody
    • ATN1L antibody
    • Atr2 antibody
    • atrophin 1 like antibody
    • Atrophin 1 like protein antibody
    • Atrophin 1 related protein antibody
    • atrophin 2 antibody
    • atrophin related protein antibody
    • ATROPHIN-1-ASSOCIATED PROTEIN antibody
    • Atrophin-1-like protein antibody
    • Atrophin-1-related protein antibody
    • atrophin-2 antibody
    • ATROPHIN-RELATED PROTEIN antibody
    • AW742570 antibody
    • DNB1 antibody
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    • KIAA0458 antibody
    • mKIAA0458 antibody
    • OTTHUMP00000001701 antibody
    • Rere antibody
    • RERE_HUMAN antibody
    see all

Anti-RERE antibody 图像

  • Anti-RERE antibody (ab103462) at 1/100 dilution + Neuro 2a cell line lysate at 35 µg

    Predicted band size : 172 kDa
  • ab103462, at a 1/50 dilution, staining RERE in formalin fixed and paraffin embedded lung carcinoma tissue by Immunohistochemistry. Developed using peroxidase conjugated secondary antibody and DAB staining.

Anti-RERE antibody (ab103462)参考文献

ab103462 has not yet been referenced specifically in any publications.

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample Human Tissue sections (brain)
Specification brain
Fixative Paraformaldehyde
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: Tris-EDTA-Buffer pH 9,0
Permeabilization Yes - Wash-Buffer from DAKO with Tween
Username

Mr. Rudolf Jung

Verified customer

提交于 Feb 15 2013

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"