Anti-RERE抗体(ab103462)

概述

  • 产品名称
  • 描述
    兔多克隆抗体to RERE
  • 经测试应用
    适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    KLH conjugated synthetic peptide corresponding to a region within amino acids 389-418 from the N terminal region of Human RERE.

  • 阳性对照
    • Neuro-2a cell line lysates; lung carcinoma tissue

性能

应用

Our Abpromise guarantee covers the use of ab103462 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 172 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能
    Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.
  • 组织特异性
    Widely expressed. Expressed in tumor cell lines.
  • 疾病相关
    Note=A chromosomal aberration involving RERE is found in the neuroblastoma cell line. Translocation t(1;15)(p36.2;q24).
  • 序列相似性
    Contains 1 BAH domain.
    Contains 1 ELM2 domain.
    Contains 1 GATA-type zinc finger.
    Contains 1 SANT domain.
  • 结构域
    The interaction with ATN1 is mediated by the coiled coil domain.
  • 细胞定位
    Nucleus. Localized in nuclear bodies of variables size. Colocalized with PML and BAX in nuclear PODs.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 1110033A15Rik antibody
    • AI414665 antibody
    • ARG antibody
    • arginine glutamic acid dipeptide (RE) repeats antibody
    • arginine glutamic acid dipeptide repeats antibody
    • Arginine glutamic acid dipeptide repeats protein antibody
    • Arginine-glutamic acid dipeptide repeats protein antibody
    • ARGININE-GLUTAMIC ACID REPEATS-ENCODING GENE antibody
    • ARP antibody
    • ATN1L antibody
    • Atr2 antibody
    • atrophin 1 like antibody
    • Atrophin 1 like protein antibody
    • Atrophin 1 related protein antibody
    • atrophin 2 antibody
    • atrophin related protein antibody
    • ATROPHIN-1-ASSOCIATED PROTEIN antibody
    • Atrophin-1-like protein antibody
    • Atrophin-1-related protein antibody
    • atrophin-2 antibody
    • ATROPHIN-RELATED PROTEIN antibody
    • AW742570 antibody
    • DNB1 antibody
    • FLJ38775 antibody
    • KIAA0458 antibody
    • mKIAA0458 antibody
    • NEDBEH antibody
    • OTTHUMP00000001701 antibody
    • Rere antibody
    • RERE_HUMAN antibody
    see all

图片

  • Anti-RERE antibody (ab103462) at 1/100 dilution + Neuro 2a cell line lysate at 35 µg

    Predicted band size : 172 kDa
  • ab103462, at a 1/50 dilution, staining RERE in formalin fixed and paraffin embedded lung carcinoma tissue by Immunohistochemistry. Developed using peroxidase conjugated secondary antibody and DAB staining.

文献

ab103462 has not yet been referenced specifically in any publications.

客户评价及客户问答

Abcam guarantees this product to work in the species/application used in this Abreview.
Application
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample
Human Tissue sections (brain)
Specification
brain
Fixative
Paraformaldehyde
Antigen retrieval step
Heat mediated - Buffer/Enzyme Used: Tris-EDTA-Buffer pH 9,0
Permeabilization
Yes - Wash-Buffer from DAKO with Tween
Username

Mr. Rudolf Jung

Verified customer

提交于 Feb 15 2013

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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