Anti-Reptin/TIP49B/RUVB2抗体[EPR4146] (ab108962)


  • 产品名称Anti-Reptin/TIP49B/RUVB2抗体[EPR4146]
    参阅全部 Reptin/TIP49B/RUVB2 一抗
  • 描述
    兔单克隆抗体[EPR4146] to Reptin/TIP49B/RUVB2
  • 经测试应用适用于: WBmore details
    不适用于: Flow Cyt,ICC,IHC-P or IP
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide corresponding to residues in Human Reptin/TIP49B/RUVB2.

  • 阳性对照
    • HepG2, Daudi, HeLa, and SKBR-3 cell lysates
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.



Our Abpromise guarantee covers the use of ab108962 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 48 kDa (predicted molecular weight: 51 kDa).
  • 应用说明Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • 靶标

    • 功能Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL2 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2.
    • 组织特异性Ubiquitously expressed. Highly expressed in testis and thymus.
    • 序列相似性Belongs to the ruvB family.
    • 结构域The C-terminal domain is required for association with ATF2.
    • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Nucleus matrix. Nucleus > nucleoplasm. Cytoplasm. Membrane. Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol. Although it is also present in the cytoplasm and associated with the cell membranes.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 48 kDa TATA box-binding protein-interacting protein antibody
      • 48 kDa TBP-interacting protein antibody
      • 48-kDa TATA box-binding protein-interacting protein antibody
      • 48-kDa TBP-interacting protein antibody
      • 51 kDa erythrocyte cytosolic protein antibody
      • CGI-46 antibody
      • EC=3.6.1.- antibody
      • ECP-51 antibody
      • ECP51 antibody
      • Erythrocyte cytosolic protein, 51-KD antibody
      • INO80 complex subunit J antibody
      • INO80J antibody
      • MGC144733 antibody
      • MGC144734 antibody
      • MGC52995 antibody
      • mp47 antibody
      • p47 antibody
      • p47 protein antibody
      • Repressing pontin 52 antibody
      • Reptin 52 antibody
      • REPTIN antibody
      • RuvB (E coli homolog)-like 2 antibody
      • RUVB, E. coli, homolog-like 2 antibody
      • RuvB-like 2 (E. coli) antibody
      • RuvB-like 2 antibody
      • RuvB-like protein 2 antibody
      • RUVB2 antibody
      • RUVB2_HUMAN antibody
      • RUVBL2 antibody
      • RVB2 antibody
      • TAP54-beta antibody
      • TATA box-binding protein-interacting protein, 48-KD antibody
      • TBP-interacting protein, 48-KD antibody
      • TIH2 antibody
      • TIP48 antibody
      • TIP49b antibody
      • TIP60-associated protein 54-beta antibody
      • wu:fi25f01 antibody
      • zreptin antibody
      see all

    Anti-Reptin/TIP49B/RUVB2 antibody [EPR4146] 图像

    • All lanes : Anti-Reptin/TIP49B/RUVB2 antibody [EPR4146] (ab108962) at 1/1000 dilution

      Lane 1 : HepG2 cell lysate
      Lane 2 : Daudi cell lysate
      Lane 3 : HeLa cell lysate
      Lane 4 : SKBR-3 cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size : 51 kDa

    Anti-Reptin/TIP49B/RUVB2 antibody [EPR4146] (ab108962)参考文献

    This product has been referenced in:
    • Satkunanathan S  et al. Establishment of a novel cell line for the enhanced production of recombinant adeno-associated virus vectors for gene therapy. Hum Gene Ther 25:929-41 (2014). WB . Read more (PubMed: 25072415) »

    See 1 Publication for this product

    Product Wall

    There are currently no Abreviews or Questions for ab108962.
    Please use the links above to contact us or submit feedback about this product.