概述

  • 产品名称Anti-Rel B抗体
    参阅全部 Rel B 一抗
  • 描述
    兔多克隆抗体to Rel B
  • 特异性Detects endogenous levels of total Rel B protein.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide:

    LLSPG

    , corresponding to amino acids 550-554 of Human Rel B

  • 阳性对照
    • HepG2 cell extracts

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab47438 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 45 kDa (predicted molecular weight: 62 kDa).
ELISA 1/20000.

靶标

  • 功能NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49.
  • 序列相似性Contains 1 RHD (Rel-like) domain.
  • 结构域Both N- and C-terminal domains are required for transcriptional activation.
  • 翻译后修饰Phosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation.
  • 细胞定位Nucleus. Cytoplasm > cytoskeleton > centrosome. Co-localizes with NEK6 in the centrosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • I REL antibody
    • I-Rel antibody
    • IREL antibody
    • Nuclear factor of kappa light polypeptide gene enhancer in B cells 3 antibody
    • relB antibody
    • RELB_HUMAN antibody
    • Reticuloendotheliosis viral oncogene homolog B antibody
    • Transcription factor Rel B antibody
    • Transcription factor RelB antibody
    • v rel avian reticuloendotheliosis viral oncogene homolog B antibody
    • v rel reticuloendotheliosis viral oncogene homolog B antibody
    see all

Anti-Rel B antibody 图像

  • All lanes : Anti-Rel B antibody (ab47438)

    Lane 1 : HepG2 cell extract
    Lane 2 : HepG2 cell extract with peptide


    Predicted band size : 62 kDa

Anti-Rel B antibody (ab47438)参考文献

ab47438 has not yet been referenced specifically in any publications.

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