Anti-RED1抗体[2011C3a] (ab76555)


  • 产品名称
    参阅全部 RED1 一抗
  • 描述
    小鼠单克隆抗体[2011C3a] to RED1
  • 宿主
  • 经测试应用
    适用于: WB, Dot blotmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment of 50-200 amino acids from near the N-terminus of Human RED1


  • 形式
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.05% Sodium Azide
    Constituents: 1% BSA, PBS, 8.0mM Sodium phosphate, 3.0mM Potassium chloride, 140mM Sodium chloride, 1.5mM Potassium phosphate, pH 7.4
  • Concentration information loading...
  • 纯度
    Protein G purified
  • 纯化说明
    Purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum and filtered through a 0.22µm membrane.
  • 克隆
  • 克隆编号
  • 同种型
  • 研究领域


Our Abpromise guarantee covers the use of ab76555 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 81 kDa.
Dot blot Use at an assay dependent dilution.


  • 功能
    Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis.
  • 组织特异性
    Highly expressed in brain and heart and at lower levels in placenta. Fair expression in lung, liver and kidney. Detected in brain, heart, kidney, lung and liver (at protein level). Isoform 5 is high expressed in hippocampus and colon. Isoform 5 is expressed in pediatric astrocytomas and the protein has a decreased RNA-editing activity. The decrease in RNA editing correlates with the grade of malignancy of the tumors, with the high grade tumors showing lower editing is seen.
  • 序列相似性
    Contains 1 A to I editase domain.
    Contains 2 DRBM (double-stranded RNA-binding) domains.
  • 细胞定位
    Nucleus. Nucleus > nucleolus. Shuttles between nucleoli and the nucleoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ADARB 1 antibody
    • ADARB1 antibody
    • 1700057H01Rik antibody
    • ADAR2 antibody
    • ADAR2a antibody
    • ADAR2a L1 antibody
    • ADAR2a L2 antibody
    • ADAR2a L3 antibody
    • ADAR2b antibody
    • ADAR2c antibody
    • ADAR2d antibody
    • ADAR2g antibody
    • Adarb1 antibody
    • Adenosine deaminase, RNA specific, 2 antibody
    • Adenosine deaminase, RNA specific, B1 (homolog of rat RED1) antibody
    • Adenosine deaminase, RNA specific, B1 (RED1 homolog rat) antibody
    • Adenosine deaminase, RNA specific, B1 antibody
    • AW124433 antibody
    • AW558573 antibody
    • BB220382 antibody
    • D10Bwg0447e antibody
    • Double stranded RNA specific editase 1 antibody
    • Double-stranded RNA-specific editase 1 antibody
    • DRABA2 antibody
    • DRADA2 antibody
    • dsRNA adenosine deaminase antibody
    • EC 3.5.-.- antibody
    • Human dsRNA adenosine deaminase DRADA2 antibody
    • Human dsRNA adenosine deaminase DRADA2b, EC 3.5 antibody
    • OTTHUMP00000115341 antibody
    • OTTHUMP00000115342 antibody
    • RED 1 antibody
    • RED1_HUMAN antibody
    • RNA editase antibody
    • RNA editase 1 antibody
    • RNA editing deaminase 1 antibody
    • RNA editing enzyme 1 antibody
    • RNA editing enzyme 1, rat, homolog of antibody
    • RNA specific adenosine deaminase B1 antibody
    • RNA-editing deaminase 1 antibody
    • RNA-editing enzyme 1 antibody
    see all


  • Anti-RED1 antibody [2011C3a] (ab76555) + immunizing recombinant protein fragment

    Predicted band size: 81 kDa

    The molecular weight of the band on the western blot does not correspond to the molecular weight of the natural protein because only a fragment of the protein was used.



ab76555 has not yet been referenced specifically in any publications.


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