概述

  • 产品名称Anti-Red Blood Cells抗体[34-3C]
    参阅全部 Red Blood Cells 一抗
  • 描述
    小鼠单克隆抗体[34-3C] to Red Blood Cells
  • 特异性Recognizes an exposed surface determinant of intact Red Blood Cells. ab106101 only recognises antigenic determinants expressed on Mouse RBC and not on other species of RBC.
  • 经测试应用适用于: Functional Studies, Flow Cytmore details
  • 种属反应性
    与反应: Mouse
    不与反应: Rat, Sheep, Rabbit, Chicken, Human
  • 免疫原

    Mouse Red Blood Cells

  • 阳性对照
    • Mouse erythrocytes
  • 常规说明


    This antibody efficiently binds to Fc receptors on macrophages inducing anemia in vivo due to a rapid Fc receptor (FcyR)-mediated erythrophagocytosis of opsonised RBC in spleen and livers. The capacity of the antibody to interact with FcyR is responsible for its haemolytic activity.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 0.1% BSA, PBS
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明0.2 µm filtered solution
  • Primary antibody说明This antibody efficiently binds to Fc receptors on macrophages inducing anemia in vivo due to a rapid Fc receptor (FcyR)-mediated erythrophagocytosis of opsonised RBC in spleen and livers. The capacity of the antibody to interact with FcyR is responsible for its haemolytic activity.
  • 克隆单克隆
  • 克隆编号34-3C
  • 同种型IgG2a
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab106101 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Functional Studies Use at an assay dependent concentration.
Flow Cyt 1/50. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

靶标

  • 相关性Red blood cells are the most common type of blood cell and are the vertebrate body's principal means of delivering oxygen from the lungs or gills to body tissues via the blood.
  • 别名
    • Erythrocytes antibody
    • RBCs antibody

Anti-Red Blood Cells antibody [34-3C] (ab106101)参考文献

This product has been referenced in:
  • Baudino L  et al. Differential contribution of three activating IgG Fc receptors (FcgammaRI, FcgammaRIII, and FcgammaRIV) to IgG2a- and IgG2b-induced autoimmune hemolytic anemia in mice. J Immunol 180:1948-53 (2008). Read more (PubMed: 18209093) »
  • Azeredo da Silveira S  et al. Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody. J Exp Med 195:665-72 (2002). Read more (PubMed: 11901193) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"