Anti-Red Blood Cells抗体[34-3C] (ab106101)
Key features and details
- Mouse monoclonal [34-3C] to Red Blood Cells
- Suitable for: Flow Cyt, Functional Studies
- Reacts with: Mouse
- Isotype: IgG2a
概述
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产品名称
Anti-Red Blood Cells抗体[34-3C]
参阅全部 Red Blood Cells 一抗 -
描述
小鼠单克隆抗体[34-3C] to Red Blood Cells -
宿主
Mouse -
特异性
Recognizes an exposed surface determinant of intact Red Blood Cells. ab106101 only recognises antigenic determinants expressed on Mouse RBC and not on other species of RBC. -
经测试应用
适用于: Flow Cyt, Functional Studiesmore details -
种属反应性
与反应: Mouse
不与反应: Rat, Sheep, Rabbit, Chicken, Human -
免疫原
Tissue, cells or virus corresponding to Mouse Red Blood Cells.
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阳性对照
- Mouse erythrocytes
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常规说明
This antibody efficiently binds to Fc receptors on macrophages inducing anemia in vivo due to a rapid Fc receptor (FcyR)-mediated erythrophagocytosis of opsonised RBC in spleen and livers. The capacity of the antibody to interact with FcyR is responsible for its haemolytic activity.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Constituents: 0.1% BSA, PBS -
Concentration information loading...
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纯度
Protein G purified -
纯化说明
0.2 µm filtered solution -
Primary antibody说明
This antibody efficiently binds to Fc receptors on macrophages inducing anemia in vivo due to a rapid Fc receptor (FcyR)-mediated erythrophagocytosis of opsonised RBC in spleen and livers. The capacity of the antibody to interact with FcyR is responsible for its haemolytic activity. -
克隆
单克隆 -
克隆编号
34-3C -
同种型
IgG2a -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab106101于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
Flow Cyt |
Use at an assay dependent concentration.
ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
|
Functional Studies |
Use at an assay dependent concentration.
|
说明 |
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Flow Cyt
Use at an assay dependent concentration. ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
Functional Studies
Use at an assay dependent concentration. |
靶标
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相关性
Red blood cells are the most common type of blood cell and are the vertebrate body's principal means of delivering oxygen from the lungs or gills to body tissues via the blood. -
别名
- Erythrocytes antibody
- RBCs antibody
数据表及文件
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Datasheet download
文献 (4)
ab106101 被引用在 4 文献中.
- Akter J et al. Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells. PLoS Pathog 15:e1007599 (2019). PubMed: 30811498
- Baudino L et al. Differential contribution of three activating IgG Fc receptors (FcgammaRI, FcgammaRIII, and FcgammaRIV) to IgG2a- and IgG2b-induced autoimmune hemolytic anemia in mice. J Immunol 180:1948-53 (2008). PubMed: 18209093
- Azeredo da Silveira S et al. Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody. J Exp Med 195:665-72 (2002). PubMed: 11901193
- Fossati-Jimack L et al. High pathogenic potential of low-affinity autoantibodies in experimental autoimmune hemolytic anemia. J Exp Med 190:1689-96 (1999). PubMed: 10587359