Recombinant Ubiquitin protein (AMCA) (ab123748)

概述

描述

  • 性质Recombinant
  • 来源Synthetic
  • 氨基酸序列
    • 偶联物AMCA. Ex: 350nm, Em: 445nm

    技术指标

    Our Abpromise guarantee covers the use of ab123748 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • 应用

      HPLC

      Functional Studies

    • 纯度70 - 90% by HPLC.
      ab123748 is prepared by the C-terminal derivatisation of ubiquitin with 7-amino-4-methylcoumarin. Purity is greater than 95% as determined by HPLC.
    • 形式Liquid
    • Concentration information loading...

    制备和贮存

    • 稳定性和存储

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      Constituent: 99% DMSO

    常规信息

    • 别名
      • FLJ25987
      • MGC8385
      • Polyubiquitin B
      • RPS 27A
      • RPS27A
      • UBA 52
      • UBA 80
      • UBA52
      • UBA80
      • UBB
      • UBB_HUMAN
      • UBC
      • UBCEP 1
      • UBCEP 2
      • UBCEP1
      • UBCEP2
      • Ubiquitin
      • Ubiquitin B
      see all
    • 相关性Function: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. Similarity: Belongs to the ubiquitin family. Contains 3 ubiquitin-like domains.
    • 细胞定位Cell Membrane, Cytoplasmic and Nuclear

    Recombinant Ubiquitin protein (AMCA) (ab123748)参考文献

    ab123748 has not yet been referenced specifically in any publications.

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