The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. Purity >98% (HPLC)
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Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
复溶reconstitute with 0.1ml water.
Maxi K channel
Potassium large conductance calcium-activated channel
相关性Slotoxin is a peptide from Centruroides noxius Hoffmann scorpion venom. It belongs to the short scorpion toxin superfamily.
The 37 amino acid peptide belongs to the charybdotoxin sub-family (alphaKTx1) and was numbered member 11. alphaKTx1.11 revealed specificity for mammalian MaxiK channels (hSlo), thus, was named slotoxin.
Slotoxin reversibly blocks the high conductance calcium-activated potassium channels composed of only alpha-subunits (Kd = 1.5 nM). Unreversibly blocks the high conductance calcium-activated potassium channels composed of alpha- and beta1-subunits. Unreversibly and weakly blocks the high conductance calcium-activated potassium channels composed of alpha- and beta4-subunits. It shows no activity on other potassium channels.
Recombinant Slotoxin protein (ab54262)参考文献
has not yet been referenced specifically in any publications.