E1-SUMO protein is a heterodimer consisted of human AOS1 and UBA2. The dimeric enzyme acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2.
Recombinant S. cerevisiae AOS1+UBA2 protein (Chemical Free) (ab80763)参考文献
has not yet been referenced specifically in any publications.