Recombinant大鼠Hsp60 protein (ab92365)



  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Rat


Our Abpromise guarantee covers the use of ab92365 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性ATPase Activity Assay: Positive
  • 应用

    Western blot

    Functional Studies


  • 纯度> 90 % SDS-PAGE.
    >90 % pure as determined by SDS-PAGE and Western blot analyses. This protein does not contain E. coli GroEL as demonstrated by western blot analysis.
  • 形式Liquid
  • Concentration information loading...


  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50mM Tris HCl, 150mM Sodium chloride, 1mM DTT, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.


  • 别名
    • 60 kDa chaperonin
    • 60 kDa heat shock protein, mitochondrial
    • CH60_HUMAN
    • Chaperonin 60
    • Chaperonin, 60-KD
    • CPN60
    • fa04a05
    • GROEL
    • heat shock 60kDa protein 1 (chaperonin)
    • Heat shock protein 1 (chaperonin)
    • Heat shock protein 60
    • Heat shock protein 65
    • heat shock protein family D (Hsp60) member 1
    • HLD4
    • Hsp 60
    • HSP 65
    • HSP-60
    • HSP60
    • HSP65
    • HSPD1
    • HuCHA60
    • Mitochondrial matrix protein P1
    • P60 lymphocyte protein
    • short heat shock protein 60 Hsp60s1
    • SPG13
    see all
  • 功能Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.
  • 疾病相关Defects in HSPD1 are a cause of spastic paraplegia autosomal dominant type 13 (SPG13) [MIM:605280]. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
    Defects in HSPD1 are the cause of leukodystrophy hypomyelinating type 4 (HLD4) [MIM:612233]; also called mitochondrial HSP60 chaperonopathy or MitCHAP-60 disease. HLD4 is a severe autosomal recessive hypomyelinating leukodystrophy. Clinically characterized by infantile-onset rotary nystagmus, progressive spastic paraplegia, neurologic regression, motor impairment, profound mental retardation. Death usually occurrs within the first two decades of life.
  • 序列相似性Belongs to the chaperonin (HSP60) family.
  • 细胞定位Mitochondrion matrix.
  • Information by UniProt

Recombinant rat Hsp60 protein 图像

  • SDS-PAGE Analysis:
    Lane 1: Molecular weight markers
    Lane 2: ab92365 at 2.0 µg
  • All lanes : Hsp60 monoclonal antibody at 1 µg/ml

    Lane 1 : Molecular weight markers
    Lane 2 : ab92365 at 0.1 µg
    Lane 3 : E. coli GroEL Protein at 0.1 µg
  • All lanes : GroEL monoclonal antibody at 1 µg/ml

    Lane 1 : Molecular weight markers
    Lane 2 : ab92365 at 0.1 µg
    Lane 3 : E. coli GroEL Protein at 0.1 µg

Recombinant rat Hsp60 protein (ab92365)参考文献

ab92365 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting Abcam about HSP60 protein endotoxin levels. We have not performed endotoxin testing on ab92365 but we have tested ab113192.  For ab113192, the endotoxin level is >500EU/mg purified protein (LAL test).   If there is anything els...

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