重组大鼠GsaSLeu212蛋白(ab90796)

概述

  • 产品名称
    重组大鼠GsaSLeu212蛋白
  • 蛋白长度
    Full length protein
  • 描述
    重组大鼠GsαSLeu212蛋白

描述

  • 性质
    Recombinant
  • 来源
    Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属
      Rat

技术指标

Our Abpromise guarantee covers the use of ab90796 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Functional Studies

  • 形式
    Liquid
  • 补充说明


    The exchange of Gln212 to Leu212 inhibits the intrinsic GTPase activity, resulting in a constitutively activated Galpha, and increases GDP-affinity of Galpha.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4

常规信息

  • 别名
    • Adenylate cyclase stimulating G alpha protein
    • AHO
    • C20orf45
    • dJ309F20.1.1
    • dJ806M20.3.3
    • Extra large alphas protein
    • GNAS
    • GNAS complex locus
    • GNAS1
    • GPSA
    • Gs alpha subunit
    • GSA
    • GSP
    • Guanine nucleotide binding protein (G protein) alpha stimulating activity polypeptide 1
    • Guanine nucleotide binding protein alpha stimulating activity polypeptide 1
    • Guanine nucleotide binding protein G(s) subunit alpha isoforms short
    • Guanine nucleotide binding protein G(s) subunit alpha isoforms XLas
    • Guanine nucleotide regulatory protein
    • MGC33735
    • PHP1A
    • PHP1B
    • POH
    • Secretogranin VI
    • XLalphas
    see all
  • 相关性
    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
  • 细胞定位
    Cell membrane; Lipid-anchor

文献

ab90796 has not yet been referenced specifically in any publications.

客户评价及客户问答

Thank you for contacting Abcam.

The only unmodified version of the protein that we have in our catalogue is ab90723, so that might be the best of them to use. However be aware that although the datasheet says that the protein is full length, ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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