The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
生物活性The biological activity of ab88005 was determined in a chemotaxis assay using a Boyden chamber with freshly isolated swine PBMCs using a Percoll gradient method. Bioactivity is typically detected at 30 ng/mL steadily, increasing through 1 ug/mL.
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
复溶Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
C-C motif chemokine 2
Chemokine (C C motif) ligand 2
Monocyte chemoattractant protein 1
Monocyte chemotactic and activating factor
Monocyte chemotactic protein 1
Monocyte secretory protein JE
Small inducible cytokine A2
Small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig je)
Small inducible cytokine subfamily A (Cys Cys), member 2
Small-inducible cytokine A2
功能Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
序列相似性Belongs to the intercrine beta (chemokine CC) family.
翻译后修饰Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.