Recombinant NGF protein (ab9796)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli

相关产品

技术指标

Our Abpromise guarantee covers the use of ab9796 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性

    Determined by the dose-dependent stimulation of the proliferation of human TF-1 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.

  • 应用

    Functional Studies

    SDS-PAGE

  • 形式Lyophilised
  • 补充说明The ED50 was determined by its ability to stimulate chick E9 DRG neurite outgrowth. The ED50 is < 1.0 ng/ml, corresponding to a specific activity of > 1 x 106 units/mg.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    n/a

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 复溶Please reconstitute this product in 200ul sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.

常规信息

  • 别名
    • Beta nerve growth factor
    • Beta NGF
    • Beta-nerve growth factor
    • Beta-NGF
    • HSAN5
    • MGC161426
    • MGC161428
    • Nerve growth factor
    • Nerve growth factor (beta polypeptide)
    • Nerve growth factor beta
    • Nerve growth factor beta polypeptide
    • Nerve growth factor beta subunit
    • NGF
    • NGF_HUMAN
    • NGFB
    • NID67
    see all
  • 功能Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).
  • 疾病相关Neuropathy, hereditary sensory and autonomic, 5
  • 序列相似性Belongs to the NGF-beta family.
  • 细胞定位Secreted.
  • Information by UniProt

Recombinant NGF protein (ab9796)参考文献

ab9796 has not yet been referenced specifically in any publications.

Product Wall

Ab9796 is a noncovalently disulfide-linked homodimer, of two 13.5kDa polypeptide monomers (238 total amino acid residues). The three disulfide bonds are required for biological activity.

As you have probably seen from the online datasheet, ab9796 -- NGF beta (human) recombinant protein -- is not currently in stock. The lead time for this item would be approx 7 working days. If you were to order 6 units on a single purchase order I coul...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"