Recombinant小鼠Tau tubulin kinase 2 protein (ab125631)

概述

  • 产品名称Recombinant小鼠Tau tubulin kinase 2 protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • AccessionQ3UVR3
    • 种属Mouse
    • 分子量88 kDa including tags
    • 氨基酸70 to 538
    • 标签GST tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab125631 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性The specific activity of ab125631 was determined to be 370 nmol/min/mg.
  • 应用

    Western blot

    Functional Studies

    SDS-PAGE

  • 纯度> 95 % Densitometry.
    >95% by Densitometry,
  • 形式Liquid
  • 补充说明

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • KIAA0847
    • mKIAA0847
    • SCA11
    • Spinocerebellar ataxia 11
    • Tau tubulin kinase 2
    • Tau-tubulin kinase 2
    • TTBK
    • TTBK 2
    • TTBK1
    • TTBK2
    • TTBK2_HUMAN
    • TTK
    see all
  • 功能Serine/threonine kinase which is able to phosphorylate tau on serines.
  • 疾病相关Defects in TTBK2 are the cause of spinocerebellar ataxia type 11 (SCA11) [MIM:604432]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA11 is an autosomal dominant cerebellar ataxia (ADCA). It is a relatively benign, late-onset, slowly progressive neurologic disorder.
  • 序列相似性Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • Information by UniProt

Recombinant mouse Tau tubulin kinase 2 protein 图像

  • SDS-PAGE of ab125631
  • The specific activity of ab125631 was determined to be 370 nmol/min/mg.

Recombinant mouse Tau tubulin kinase 2 protein (ab125631)参考文献

ab125631 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab125631.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"