Recombinant小鼠SOD2/MnSOD protein (ab113179)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP09671
    • 种属Mouse
    • 分子量25 kDa including tags
    • 氨基酸1 to 222
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab113179 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Superoxide dismutase >2500units/mg
  • 应用

    Western blot

    Functional Studies

    SDS-PAGE

  • 纯度> 90 % SDS-PAGE.
    ab113179 is purified by multi-step chromatography.
  • 形式Liquid
  • 补充说明 Superoxide dismutase >2500units/mg
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.79% Tris HCl, 1.5% Glycerol, 0.47% Sodium chloride

常规信息

  • 别名
    • Indophenoloxidase B
    • IPO B
    • IPOB
    • Manganese containing superoxide dismutase
    • Manganese SOD
    • Manganese superoxide dismutase
    • Mangano superoxide dismutase
    • Mn SOD
    • Mn superoxide dismutase
    • MNSOD
    • MVCD6
    • SOD 2
    • SOD2
    • SODM_HUMAN
    • Superoxide dismutase [Mn] mitochondrial
    • Superoxide dismutase [Mn], mitochondrial
    • Superoxide dismutase 2 mitochondrial
    see all
  • 功能Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
  • 疾病相关Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6) [MIM:612634]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
  • 序列相似性Belongs to the iron/manganese superoxide dismutase family.
  • 翻译后修饰Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
  • 细胞定位Mitochondrion matrix.
  • Information by UniProt

Recombinant Mouse SOD2/MnSOD protein 图像

  • SDS-PAGE analysis:
    Lane 1: MW marker
    Lane 2: ab113179 at 2μg
    Lane 3: ab113179 at 5μg.
  • All lanes : Anti-Superoxide Dismutase 2 antibody

    Lane 1 : Molecular Weight Markers
    Lane 2 : Mouse Brain Tissue Extract
    Lane 3 : Recombinant Mouse SOD2/MnSOD protein (ab113179)

Recombinant Mouse SOD2/MnSOD protein (ab113179)参考文献

ab113179 has not yet been referenced specifically in any publications.

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