功能Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.
序列相似性Belongs to the peptidase C48 family.
结构域The N-terminus is necessary and sufficient for nuclear envelope targeting.
翻译后修饰Polyubiquitinated; which leads to proteasomal degradation.
细胞定位Nucleus > nuclear pore complex. Nucleus membrane. Cytoplasm. Shuttles between cytoplasm and nucleus.