Recombinant小鼠Prorenin protein (ab123479)

概述

描述

  • 性质Recombinant
  • 来源HEK 293 cells
  • 氨基酸序列
    • AccessionP06281
    • 种属Mouse
    • 分子量42 kDa including tags
    • 氨基酸1 to 402
    • 标签His tag C-Terminus

技术指标

Our Abpromise guarantee covers the use of ab123479 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性One unit of protease hydrolyzes 1 picomole of Mouse renin FRET substrate 5-FAM/QXLTM 520 per minute at pH 7.5 at 25° C.
  • 应用

    Functional Studies

    SDS-PAGE

  • 形式Liquid
  • 补充说明 One unit of protease hydrolyzes 1 picomole of Mouse renin FRET substrate 5-FAM/QXLTM 520 per minute at pH 7.5 at 25° C.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituent: 0.6% Tris

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • Angiotensin forming enzyme
    • Angiotensinogenase
    • FLJ10761
    • HNFJ2
    • REN
    • Ren1
    • RENAA
    • RENI_HUMAN
    • Renin
    • Renin precursor renal
    • Renin-1
    • Renin-2
    see all
  • 功能Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
  • 疾病相关Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
    Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:613092]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.
  • 序列相似性Belongs to the peptidase A1 family.
  • 细胞定位Secreted. Membrane. Associated to membranes via binding to ATP6AP2.
  • Information by UniProt

Recombinant mouse Prorenin protein (ab123479)参考文献

ab123479 has not yet been referenced specifically in any publications.

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