Recombinant小鼠MRP8 protein (ab108120)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP27005
    • 种属Mouse
    • 序列MGSSHHHHHHSSGLVPRGSHMPSELEKALSNLIDVYHNYSNIQGNHHALY KNDFKKMVTTECPQFVQNINIENLFRELDINSDNAINFEEFLAMVIKVGV ASHKDSHKE
    • 分子量12 kDa including tags
    • 氨基酸1 to 89
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab108120 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 95 % SDS-PAGE.
    ab108120 is purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 30% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0

常规信息

  • 别名
    • 60B8Ag
    • AI323541
    • B8Ag
    • BEE11
    • CAGA
    • Calgranulin-A
    • Calprotectin L1L subunit
    • Calprotectin, included
    • CFAG
    • CGLA
    • Chemotactic cytokine CP-10
    • CP-10
    • Cystic fibrosis antigen
    • L1Ag
    • Leukocyte L1 complex light chain
    • MA387
    • MIF
    • Migration inhibitory factor-related protein 8
    • MRP-8
    • Myeloid-related protein 8
    • Neutrophil cytosolic 7 kDa protein
    • NIF
    • p8
    • Pro-inflammatory S100 cytokine
    • Protein S100-A8
    • S100 calcium binding protein A8
    • S100 calcium binding protein A8 (calgranulin A)
    • S100 calcium-binding protein A8
    • S100A8
    • S100A8/S100A9 complex, included
    • S10A8_HUMAN
    • Urinary stone protein band A
    see all
  • 功能Calcium-binding protein. Has antimicrobial activity towards bacteria and fungi. Important for resistance to invasion by pathogenic bacteria. Up-regulates transcription of genes that are under the control of NF-kappa-B. Plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS) (By similarity). Promotes tubulin polymerization. Promotes phagocyte migration and infiltration of granulocytes at sites of wounding. Plays a role as pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1. Extracellular calprotectin binds to target cells and promotes apoptosis. Antimicrobial and proapoptotic activity is inhibited by zinc ions.
  • 组织特异性Expressed by macrophages in chronic inflammations. Also expressed in epithelial cells constitutively or induced during dermatoses.
  • 序列相似性Belongs to the S-100 family.
    Contains 2 EF-hand domains.
  • 细胞定位Secreted. Cytoplasm. Cytoplasm > cytoskeleton. Cell membrane. Associates with tubulin filaments in activated monocytes. Targeted to the cell surface upon calcium influx. Released from blood leukocytes upon exposure to CSF2/GM-CSF, bacterial lipopolysaccharide (LPS) and during inflammatory processes. Serum levels are high in patients suffering from chronic inflammation.
  • Information by UniProt

Recombinant Mouse MRP8 protein 图像

  • 15% SDS-PAGE showing ab108120 at approximately 12.4kDa (3µg).

Recombinant Mouse MRP8 protein (ab108120)参考文献

ab108120 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab108120.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"