Recombinant小鼠Jagged1 protein (ab109346)

概述

描述

  • 性质Recombinant
  • 来源HEK 293 cells
  • 氨基酸序列
    • AccessionQ9QXX0
    • 种属Mouse
    • 分子量150 kDa
    • 氨基酸1 to 1067

技术指标

Our Abpromise guarantee covers the use of ab109346 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Inhibition Assay

  • 内毒素水平< 0.100 Eu/µg
  • 纯度> 90 % SDS-PAGE.
    ab109346 is an 0.2 µm filtered solution.
  • 形式Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Constituent: PBS

  • 复溶For 10µg size: reconstitute with 100µl sterile water. For 50µg size: reconstitute with 50µl sterile water

常规信息

  • 别名
    • AGS
    • AHD
    • AWS
    • CD 339
    • CD339
    • CD339 antigen
    • Headturner
    • hJ1
    • Htu
    • Jag 1
    • Jag1
    • JAG1_HUMAN
    • Jagged 1
    • Jagged1
    • Jagged1 (Alagille syndrome)
    • JAGL1
    • MGC104644
    • OTTHUMP00000030278
    • Protein jagged-1
    • Ser 1
    • Ser1
    • Serrate 1
    • Slalom
    see all
  • 功能Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).
  • 组织特异性Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.
  • 疾病相关Defects in JAG1 are the cause of Alagille syndrome type 1 (ALGS1) [MIM:118450]. Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.
    Defects in JAG1 are a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent.
  • 序列相似性Contains 1 DSL domain.
    Contains 15 EGF-like domains.
  • 发展阶段Expressed in 32-52 days embryos in the distal cardiac outflow tract and pulmonary artery, major arteries, portal vein, optic vesicle, otocyst, branchial arches, metanephros, pancreas, mesocardium, around the major bronchial branches, and in the neural tube.
  • 细胞定位Membrane.
  • Information by UniProt

Recombinant Mouse Jagged1 protein (ab109346)参考文献

ab109346 has not yet been referenced specifically in any publications.

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