Recombinant小鼠Interferon gamma protein (ab9922)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Mouse
    • 序列Recombinant Murine IFN-g is a 15.6 kDa protein containing 134 amino acid residues: MHGTVIESLE SLNNYFNSSG IDVEEKSLFL DIWRNWQKDG DMKILQSQII SFYLR LFEVLKDNQAISNNI SVIESHLITT FFSNSKAKKD AFMSIAKFEV N NPQVQRQAF NELIRVVHQLLPESSLRKRK RSRC

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技术指标

Our Abpromise guarantee covers the use of ab9922 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Functional Studies

    SDS-PAGE

  • 内毒素水平< 0.100 Eu/µg
  • 形式Lyophilised
  • 补充说明The ED50 is <0.2ng/ml, determined by ability to inhibit proliferation of murine WEHI-279 cells, corresponding to a specific activity of >5 x 106 units/mg
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    n/a

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 复溶Please reconstitute this product in 5-10mM Sodium Phosphate, pH 8.0 to a concentration of 1.0mg/ml.

常规信息

  • 别名
    • IFG
    • IFI
    • IFN gamma
    • IFN, immune
    • IFN-gamma
    • IFNG
    • IFNG_HUMAN
    • Immune interferon
    • Interferon gamma
    see all
  • 功能Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
  • 组织特异性Released primarily from activated T lymphocytes.
  • 疾病相关In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
  • 序列相似性Belongs to the type II (or gamma) interferon family.
  • 翻译后修饰Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
  • 细胞定位Secreted.
  • Information by UniProt

Recombinant mouse Interferon gamma protein (ab9922)参考文献

ab9922 has not yet been referenced specifically in any publications.

Product Wall

Abreviews
Application Functional Studies
We used the recombinant IFN-g protein in cell culture. It reconstituted easily, and worked well in vitro to stimulate cells.
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Ms. Cheryl Sandoval

Verified customer

提交于 Sep 13 2016

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"