Recombinant小鼠Hsp27 protein (ab92457)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Mouse

技术指标

Our Abpromise guarantee covers the use of ab92457 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

  • 纯度> 90 % SDS-PAGE.
    Purified by multi-step chromatography. > 90% pure as determined by SDS-PAGE and Western Blot analysis.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 1X Dulbecco's PBS

常规信息

  • 别名
    • Heat shock 27kDa protein
    • 28 kDa heat shock protein
    • CMT2F
    • DKFZp586P1322
    • epididymis secretory protein Li 102
    • Estrogen regulated 24 kDa protein
    • Estrogen-regulated 24 kDa protein
    • Heat shock 25kDa protein 1
    • Heat shock 27 kDa protein
    • Heat shock 27kD protein 1
    • Heat shock 27kDa protein 1
    • Heat shock 28kDa protein 1
    • Heat Shock Protein 27
    • Heat shock protein beta 1
    • Heat shock protein beta-1
    • heat shock protein family B (small) member 1
    • HEL-S-102
    • HMN2B
    • HS.76067
    • Hsp 25
    • HSP 27
    • Hsp 28
    • Hsp B1
    • Hsp25
    • HSP27
    • Hsp28
    • HspB1
    • HSPB1_HUMAN
    • SRP27
    • Stress responsive protein 27
    • Stress-responsive protein 27
    see all
  • 功能Involved in stress resistance and actin organization.
  • 组织特异性Detected in all tissues tested: skeletal muscle, heart, aorta, large intestine, small intestine, stomach, esophagus, bladder, adrenal gland, thyroid, pancreas, testis, adipose tissue, kidney, liver, spleen, cerebral cortex, blood serum and cerebrospinal fluid. Highest levels are found in the heart and in tissues composed of striated and smooth muscle.
  • 疾病相关Defects in HSPB1 are the cause of Charcot-Marie-Tooth disease type 2F (CMT2F) [MIM:606595]. CMT2F is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. CMT2F onset is between 15 and 25 years with muscle weakness and atrophy usually beginning in feet and legs (peroneal distribution). Upper limb involvement occurs later. CMT2F inheritance is autosomal dominant.
    Defects in HSPB1 are a cause of distal hereditary motor neuronopathy type 2B (HMN2B) [MIM:608634]. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective impairment of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.
  • 序列相似性Belongs to the small heat shock protein (HSP20) family.
  • 翻译后修饰Phosphorylated in MCF-7 cells on exposure to protein kinase C activators and heat shock.
  • 细胞定位Cytoplasm. Nucleus. Cytoplasm > cytoskeleton > spindle. Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
  • Information by UniProt

Recombinant Mouse Hsp27 protein 图像

  • SDS-PAGE Analysis:
    Lane 1: Molecular weight marker
    Lane 2: 0.5 µg ab92457
    Lane 3: 1.0 µg ab92457
    Lane 4: 2.0 µg ab92457
    Lane 5: 5.0 µg ab92457
  • All lanes : anti-Hsp25 Polyclonal Antibody

    Lane 1 : Molecular weight markers
    Lane 2 : ab92457 at 0.01 µg

Recombinant Mouse Hsp27 protein (ab92457)参考文献

ab92457 has not yet been referenced specifically in any publications.

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