Recombinant小鼠Eph receptor A1 protein (ab55900)

概述

描述

  • 性质
    Recombinant
  • 来源
    Baculovirus infected Sf9 cells
  • 氨基酸序列
    • Accession
    • 种属
      Mouse
    • 分子量
      71 kDa
    • 氨基酸
      569 to 977
    • 标签
      GST tag N-Terminus
    • 额外的序列信息
      Recombinant fragment, corresponding to amino acids 569-end of Mouse Eph receptor A1.

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技术指标

Our Abpromise guarantee covers the use of ab55900 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    Specific activity : 32 nmol/min/mg.
  • 应用

    Functional Studies

    SDS-PAGE

  • 形式
    Liquid
  • 补充说明

    ab204877 (Poly (4:1 Glu, Tyr) peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • EPH
    • EPH receptor A1
    • EPH tyrosine kinase
    • EPH tyrosine kinase 1
    • Epha1
    • EPHA1_HUMAN
    • Ephrin receptor Eph A1
    • Ephrin type A receptor 1
    • Ephrin type-A receptor 1
    • EPHT
    • EPHT 1
    • EPHT1
    • Erythropoietin producing hepatoma amplified sequence
    • Erythropoietin-producing hepatoma receptor
    • Esk
    • hEpha1
    • MGC163163
    • Oncogene EPH
    • Soluble EPHA1 variant 1
    • Soluble EPHA1 variant 2
    • Tyrosine protein kinase receptor EPH
    • Tyrosine-protein kinase receptor EPH
    see all
  • 功能
    Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
  • 组织特异性
    Overexpressed in several carcinomas.
  • 序列相似性
    Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
    Contains 1 Eph LBD (Eph ligand-binding) domain.
    Contains 2 fibronectin type-III domains.
    Contains 1 protein kinase domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • 翻译后修饰
    Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1.
    Ubiquitinated.
  • 细胞定位
    Cell membrane.
  • Information by UniProt

图片

  • Kinase assay using ab55900.
  • ab55900 on SDS-PAGE.

文献

ab55900 has not yet been referenced specifically in any publications.

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