Recombinant小鼠DKK1 protein (ab113191)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Mouse
    • 分子量
      35 kDa including tags
    • 氨基酸
      1 to 272
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab113191 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

  • 纯度
    > 95 % SDS-PAGE.
    ab113191 is purified by multi-step chromatography.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.50
    Constituents: 0.61% Tris, 0.03% DTT, 0.03% EDTA, 1.46% Sodium chloride

常规信息

  • 别名
    • Dickkopf 1
    • Dickkopf 1 homolog
    • Dickkopf 1 like
    • Dickkopf homolog 1
    • Dickkopf like protein 1
    • Dickkopf related protein 1
    • Dickkopf WNT signaling pathway inhibitor 1
    • Dickkopf-1
    • Dickkopf-related protein 1
    • DKK 1
    • Dkk-1
    • Dkk1
    • DKK1_HUMAN
    • hDkk 1
    • hDkk-1
    • SK
    see all
  • 功能
    Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • 组织特异性
    Placenta.
  • 序列相似性
    Belongs to the dickkopf family.
  • 结构域
    The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • 细胞定位
    Secreted.
  • Information by UniProt

图片

  • anti-DKK1 pAb + Recombinant Mouse DKK1 protein (ab113191) at 0.01 µg
    Developed using the ECL technique
  • SDS-PAGE showing ab113191
    Lane 1: 0.5 mg protein
    Lane 2: 1.0 mg protein
    Lane 3: 2.0 mg protein
    Lane 4: 5.0 mg protein

文献

ab113191 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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