Recombinant小鼠DKK1 protein (ab113191)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionO54908
    • 种属Mouse
    • 分子量35 kDa including tags
    • 氨基酸1 to 272
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab113191 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    ab113191 is purified by multi-step chromatography.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.50
    Constituents: 0.61% Tris, 0.03% DTT, 0.03% EDTA, 1.46% Sodium chloride

常规信息

  • 别名
    • Dickkopf 1
    • Dickkopf 1 homolog
    • Dickkopf 1 like
    • Dickkopf homolog 1
    • Dickkopf like protein 1
    • Dickkopf related protein 1
    • Dickkopf WNT signaling pathway inhibitor 1
    • Dickkopf-1
    • Dickkopf-related protein 1
    • DKK 1
    • Dkk-1
    • Dkk1
    • DKK1_HUMAN
    • hDkk 1
    • hDkk-1
    • SK
    see all
  • 功能Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • 组织特异性Placenta.
  • 序列相似性Belongs to the dickkopf family.
  • 结构域The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • 细胞定位Secreted.
  • Information by UniProt

Recombinant Mouse DKK1 protein 图像

  • anti-DKK1 pAb + Recombinant Mouse DKK1 protein (ab113191) at 0.01 µg
    Developed using the ECL technique
  • SDS-PAGE showing ab113191
    Lane 1: 0.5 mg protein
    Lane 2: 1.0 mg protein
    Lane 3: 2.0 mg protein
    Lane 4: 5.0 mg protein

Recombinant Mouse DKK1 protein (ab113191)参考文献

ab113191 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab113191.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"