The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
C5a is rapidly desarginated by serum carboxypeptidase N to the less potent derivate C5a desArg, the first stage in deactivation of anaphylatoxin activity. The C5a desArg form has a different spectrum of bioactivity to intact C5a.
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Reconstitute the vial by injection of 0.5 ml distilled or de-ionised water. Store stock solution after reconstitution in aliquots at -20°C. Repeated freeze and thaw cycles cause loss of activity.
For dilutions use protein stabilized phosphate buffered saline, pH 7.4.
Anaphylatoxin C5a analog
Complement C5 precursor
Complement component 5
Complement component C5a
C5 is involved in the activation of the lytic pathway within the complement system, which is an important factor in innate immunity.
has not yet been referenced specifically in any publications.