Recombinant小鼠Bad protein (ab58730)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • 种属
      Mouse

技术指标

Our Abpromise guarantee covers the use of ab58730 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 250mM Imidizole, PBS

常规信息

  • 别名
    • AI325008
    • BAD
    • BAD_HUMAN
    • BBC 2
    • BBC2
    • BBC6
    • Bcl 2 Antagonist of Cell Death
    • Bcl 2 Binding Component 6
    • BCL X / BCL 2 Binding Protein
    • BCL X Binding Protein
    • Bcl XL/Bcl 2 Associated Death Promoter
    • Bcl-2-binding component 6
    • Bcl-2-like protein 8
    • Bcl-XL/Bcl-2-associated death promoter
    • Bcl2 antagonist of cell death
    • BCL2 antagonist of cell death protein
    • BCL2 associated agonist of cell death
    • Bcl2 Associated Death Promoter
    • BCL2 binding component 6
    • BCL2 binding protein
    • Bcl2 Like 8 Protein
    • Bcl2-L-8
    • BCL2L8
    • Proapoptotic BH3 Only Protein
    see all
  • 功能
    Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
  • 组织特异性
    Expressed in a wide variety of tissues.
  • 序列相似性
    Belongs to the Bcl-2 family.
  • 结构域
    Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
  • 翻译后修饰
    Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation. Ser-75 is phosphorylated by AKT/PKB, protein kinase A and PIM2.
  • 细胞定位
    Mitochondrion outer membrane. Cytoplasm. Upon phosphorylation, locates to the cytoplasm.
  • Information by UniProt

文献

ab58730 has not yet been referenced specifically in any publications.

客户评价及客户问答

There are currently no Customer reviews or Questions for ab58730.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册