Recombinant Menin protein (ab114387)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 序列
      MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFL AVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIR GAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFIT GTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWSWLYLKGSYMRCDRK MEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNL ADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRN VREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLL EAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLH VGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGP RRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGS TAQVPAPAASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQS QVQMKKQKVSTPSDYTLSFLKRQRKGL
    • 分子量
      89 kDa
    • 氨基酸
      1 to 575

相关产品

技术指标

Our Abpromise guarantee covers the use of ab114387 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

    ELISA

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml.
    ab114387 is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

常规信息

  • 别名
    • MEA 1
    • MEA1
    • MEN 1
    • Men1
    • MEN1_HUMAN
    • Menin
    • Multiple Endocrine Adenomatosis 1
    • Multiple Endocrine Neoplasia 1
    • SCG 2
    • SCG2
    • Suppressor Candidate Gene 2
    • Wermer syndrome
    • ZES
    • Zollinger Ellison Syndrome
    see all
  • 功能
    Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.
  • 组织特异性
    Ubiquitous.
  • 疾病相关
    Defects in MEN1 are the cause of familial multiple endocrine neoplasia type I (MEN1) [MIM:131100]. Autosomal dominant disorder characterized by tumors of the parathyroid glands, gastro-intestinal endocrine tissue, the anterior pituitary and other tissues. Cutaneous lesions and nervous-tissue tumors can exist. Prognosis in MEN1 patients is related to hormonal hypersecretion by tumors, such as hypergastrinemia causing severe peptic ulcer disease (Zollinger-Ellison syndrome, ZES), primary hyperparathyroidism, and acute forms of hyperinsulinemia.
    Defects in MEN1 are the cause of familial isolated hyperparathyroidism (FIHP) [MIM:145000]; also known as hyperparathyroidism type 1 (HRPT1). FIHP is an autosomal dominant disorder characterized by hypercalcemia, elevated parathyroid hormone (PTH) levels, and uniglandular or multiglandular parathyroid tumors.
  • 翻译后修饰
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位
    Nucleus. Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation.
  • Information by UniProt

图片

  • ab114387 analysed on a 12.5% SDS-PAGE Stained with Coomassie Blue.

文献

ab114387 has not yet been referenced specifically in any publications.

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