Recombinant人Y14 protein (ab105606)

概述

  • 产品名称Recombinant人Y14 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ9Y5S9
    • 种属Human
    • 序列MADVLDLHEA GGEDFAMDED GDESIHKLKE KAKKRKGRGF GSEEGSRARM REDYDSVEQD GDEPGPQRSV EGWILFVTGV HEEATEEDIH DKFAEYGEIK NIHLNLDRRT GYLKGYTLVE YETYKEAQAA MEGLNGQDLM GQPISVDWCF VRGPPKGKRR GGRRRSRSPD RRRRLEHHHH HH
    • 分子量21 kDa including tags
    • 氨基酸1 to 174
    • 标签His tag C-Terminus

技术指标

Our Abpromise guarantee covers the use of ab105606 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.
    ab105606 is purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0

常规信息

  • 别名
    • Binder of OVCA1 1
    • Binder of OVCA1-1
    • BOV 1
    • BOV 1A
    • BOV 1B
    • BOV 1C
    • BOV-1
    • BOV1
    • BOV1A
    • BOV1B
    • BOV1C
    • HSPC 114
    • HSPC114
    • MDS 014
    • MDS014
    • RBM 8
    • RBM 8A
    • RBM 8B
    • RBM8
    • rbm8a
    • RBM8A_HUMAN
    • RBM8B
    • Ribonucleoprotein RBM 8
    • Ribonucleoprotein RBM 8A
    • Ribonucleoprotein RBM8
    • Ribonucleoprotein RBM8A
    • RNA binding motif protein 8
    • RNA binding motif protein 8A
    • RNA binding motif protein 8B
    • RNA binding protein 8A
    • RNA binding protein Y14
    • RNA-binding motif protein 8A
    • RNA-binding protein 8A
    • RNA-binding protein Y14
    • ZNRP
    • ZRNP 1
    • ZRNP1
    see all
  • 功能Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The heterodimer MAGOH-RBM8A interacts with PYM that function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Remains associated with mRNAs in the cytoplasm until the mRNAs engage the translation machinery. Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. Complex with MAGOH is a component of the nonsense mediated decay (NMD) pathway.
  • 组织特异性Ubiquitous.
  • 序列相似性Belongs to the RBM8A family.
    Contains 1 RRM (RNA recognition motif) domain.
  • 细胞定位Nucleus. Nucleus speckle. Cytoplasm. Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.
  • Information by UniProt

Recombinant Human Y14 protein 图像

  • 15% SDS-PAGE showing ab105606 (3 µg) at approximately 20.9 kDa.

Recombinant Human Y14 protein (ab105606)参考文献

ab105606 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"