Recombinant人WWP1 protein (ab95931)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus
  • 氨基酸序列
    • AccessionQ9H0M0
    • 种属Human
    • 分子量106 kDa including tags
    • 氨基酸2 to 922
    • 标签DDDDK tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab95931 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on Dry Ice. Store at -80°C.

    pH: 8.00
    Constituents: 20% Glycerol, 0.58% Sodium chloride, 0.395% Tris HCl, 0.05% Tween, 0.0462% DTT
    Note: 103 µg/ml FLAG peptide

常规信息

  • 别名
    • AIP 5
    • AIP5
    • Atropin-1-interacting protein 5
    • hSDRP1
    • Nedd 4 like ubiquitin protein ligase
    • nedd4 like
    • NEDD4-like E3 ubiquitin-protein ligase WWP1
    • TGIF interacting ubiquitin ligase 1
    • Tiul1
    • WW domain containing E3 ubiquitin protein ligase 1
    • WW domain-containing protein 1
    • WWP 1
    see all
  • 相关性WWP1 is an E3 ubiquitin ligase and belongs to a family of NEDD4-like proteins. WWP1 contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. The HECT domain of WWP1 has been implicated in regulating the localization and stability of p53 – inhibition of WWP1 results in a decrease in p53 expression, whilst WWP1 mediated stabilization of p53 appears to be associated with an accumulation of cytoplasmic p53. WWP1 also negatively regulates the TGF beta tumor suppressor pathway by inactivating its molecular components (SMAD2, SMAD4 and TGFbetaR1). WWP1 has been implicated in both breast and prostate cancers.
  • 细胞定位Cell Membrane, Cytoplasmic and Nuclear

Recombinant Human WWP1 protein 图像

  • 10% SDS-PAGE showing ab95931 at approximately 106kDa (1µg).

Recombinant Human WWP1 protein (ab95931)参考文献

ab95931 has not yet been referenced specifically in any publications.

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