The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
生物活性The biological activity of ab116171 is determined by its ability to inhibit Wnt3a induced alkaline phosphatase production in MC3T3-E1 cells. The expected ED50 for this effect is 40-60 ng/ml.
内毒素水平< 0.100 Eu/µg
% SDS-PAGE. The purity of ab116171 is greater than 80% by SDS-PAGE gel and HPLC analyses.
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Shipped at 4°C. Store at -20ºC.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
复溶Reconstitute to a concentration of 0.1 mg/ml.
Protein Wnt-7a precursor
Proto oncogene Wnt7a protein
proto-oncogene wnt7a protein
wingless-type MMTV integration site family, member 7A
功能Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts.
组织特异性Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain.
疾病相关Defects in WNT7A are the cause of limb/pelvis-hypoplasia/aplasia syndrome (LPHAS) [MIM:276820]; also known as absence of ulna and fibula with severe limb deficiency. LPHAS is a limb-malformation disorder characterized by various degrees of limb aplasia/hypoplasia and joint dysplasia. Defects in WNT7A are a cause of Fuhrmann syndrome (FUHRS) [MIM:228930]; also known as fibular aplasia or hypoplasia femoral bowing and poly- syn- and oligodactyly. Fuhrmann syndrome is a distinct limb-malformation disorder characterized also by various degrees of limb aplasia/hypoplasia and joint dysplasia.
序列相似性Belongs to the Wnt family.
细胞定位Secreted > extracellular space > extracellular matrix.