Recombinant人WISP3 protein (ab50049)

概述

  • 产品名称Recombinant人WISP3 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 序列TGPLDTTPEG RPGEVSDAPQ RKQFCHWPCK CPQQKPRCPP GVSLVRDGCG CCKICAKQPG EICNEADLCD PHKGLYCDYS VDRPRYETGV CAYLVAVGCE FNQVHYHNGQ VFQPNPLFSC LCVSGAIGCT PLFIPKLAGS HCSGAKGGKK SDQSNCSLEP LLQQLSTSYK TMPAYRNLPL IWKKKCLVQA TKWTPCSRTC GMGISNRVTN ENSNCEMRKE KRLCYIQPCD SNILKTIKIP KGKTCQPTFQ LSKAEKFVFS GCSSTQSYKP TFCGICLDKR CCIPNKSKMI TIQFDCPNEG SFKWKMLWIT SCVCQRNCRE PGDIFSELKI L

相关产品

技术指标

Our Abpromise guarantee covers the use of ab50049 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Biological Activity : The ED50 was determined by the dose-dependant proliferation of the MCF-7 cell line. The expected ED50 for this effect is 0.2-0.3 µg/ml.
  • 应用

    SDS-PAGE

    Functional Studies

  • 内毒素水平< 0.100 Eu/µg
  • 形式Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C long term.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • CCN 6
    • CCN family member 6
    • CCN6
    • CYR61
    • LIBC
    • Lost in inflammatory breast cancer tumor suppressor protein
    • MGC125987
    • MGC125988
    • MGC125989
    • OTTHUMP00000040421
    • PPAC
    • PPD
    • UNQ462/PRO790/PRO956
    • WISP 3
    • WISP-3
    • WISP3
    • WISP3_HUMAN
    • WNT 1 inducible signaling pathway protein 3
    • Wnt 1 signaling pathway protein 3
    • WNT1 inducible signaling pathway protein 3
    • WNT1 inducible signaling pathway protein 3 precursor
    • WNT1-inducible-signaling pathway protein 3
    see all
  • 功能Appears to be required for normal postnatal skeletal growth and cartilage homeostasis.
  • 组织特异性Predominant expression in adult kidney and testis and fetal kidney. Weaker expression found in placenta, ovary, prostate and small intestine. Also expressed in skeletally-derived cells such as synoviocytes and articular cartilage chondrocytes.
  • 疾病相关Defects in WISP3 are the cause of progressive pseudorheumatoid arthropathy of childhood (PPAC) [MIM:208230]. PPAC is an autosomal recessive disorder characterized by stiffness and swelling of joints, motor weakness and joint contractures. Signs and symptoms of the disease develop typically between three and eight years of age. This progressive disease is a primary disorder of articular cartilage with continued cartilage loss and destructive bone changes with aging.
  • 序列相似性Belongs to the CCN family.
    Contains 1 CTCK (C-terminal cystine knot-like) domain.
    Contains 1 IGFBP N-terminal domain.
    Contains 1 TSP type-1 domain.
  • 细胞定位Secreted.
  • Information by UniProt

Recombinant human WISP3 protein (ab50049)参考文献

ab50049 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your telephone enquiry yesterday afternoon. I can confirm that our ab50049 WISP3 human protein (Active) has been tested for biological activity in cell culture, so it will be covered by our guarantee for this application. The orig...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"