概述

  • 产品名称Recombinant人WISP1 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 序列TALSPAPTTM DFTPAPLEDT SSRPQFCKWP CECPPSPPRC PLGVSLITDG CECCKMCAQQ LGDNCTEAAI CDPHRGLYCD YSGDRPRYAI GVCAQVVGVG CVLDGVRYNN GQSFQPNCKY NCTCIDGAVG CTPLCLRVRP PRLWCPHPRR VSIPGHCCEQ WVCEDDAKRP RKTAPRDTGA FDAVGEVEAW HRNCIAYTSP WSPCSTSCGL GVSTRISNVN AQCWPEQESR LCNLRPCDVD IHTLIKAGKK CLAVYQPEAS MNFTLAGCIS TRSYQPKYCG VCMDNRCCIP YKSKTIDVSF QCPDGLGFSR QVLWINACFC NLSCRNPNDI FADLESYPDF SEIAN

技术指标

Our Abpromise guarantee covers the use of ab50041 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Biological Activity : The ED50 was determined by the dose-dependant proliferation of the MCF-7 cell line. The expected ED50 for this effect is 1.0-3.0 µg/ml.
  • 应用

    SDS-PAGE

    Functional Studies

  • 内毒素水平< 0.100 Eu/µg
  • 形式Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C long term.

    Preservative: None
    Constituents: 10mM Acetic acid

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 复溶Reconstitute product with 10mM Acetic Acid.

常规信息

  • 别名
    • CCN 4
    • CCN family member 4
    • CCN4
    • WISP 1
    • WISP 1c
    • WISP 1i
    • WISP 1tc
    • WISP1c
    • WISP1i
    • WISP1tc
    • Wnt 1 induced secreted protein
    • WNT 1 induced secreted protein 1
    • WNT 1 inducible signaling pathway protein 1
    • Wnt 1 signaling pathway protein 1
    • Wnt-1 inducible signaling pathway protein 1
    • Wnt1 induced secreted protein
    • WNT1 induced secreted protein 1
    • WNT1 inducible signaling pathway protein 1
    • Wnt1 signaling pathway protein 1
    • WNT1-inducible-signaling pathway protein 1
    see all
  • 相关性WISP1 is a downstream regulator in the Wnt/Frizzled-signaling pathway and is associated with cell survival. WISP1 attentuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase and up-regulates the anti-apoptotic Bcl-X(L) protein. WISP1 is expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Overexpression is associated with several cancers including breast cancer and colon tumors.
  • 细胞定位Secreted

Recombinant human WISP1 protein (ab50041)参考文献

This product has been referenced in:
  • Li WF  et al. WISP-1 contributes to fractionated irradiation-induced radioresistance in esophageal carcinoma cell lines and mice. PLoS One 9:e94751 (2014). ICC/IF ; Mouse, Human . Read more (PubMed: 24728101) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"