The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological Activity : The ED50 was determined by the dose-dependant proliferation of the MCF-7 cell line. The expected ED50 for this effect is 1.0-3.0 µg/ml.
< 0.100 Eu/µg
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Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C long term.
Constituents: 10mM Acetic acid
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Reconstitute product with 10mM Acetic Acid.
CCN family member 4
Wnt 1 induced secreted protein
WNT 1 induced secreted protein 1
WNT 1 inducible signaling pathway protein 1
Wnt 1 signaling pathway protein 1
Wnt-1 inducible signaling pathway protein 1
Wnt1 induced secreted protein
WNT1 induced secreted protein 1
WNT1 inducible signaling pathway protein 1
Wnt1 signaling pathway protein 1
WNT1-inducible-signaling pathway protein 1
WISP1 is a downstream regulator in the Wnt/Frizzled-signaling pathway and is associated with cell survival. WISP1 attentuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase and up-regulates the anti-apoptotic Bcl-X(L) protein. WISP1 is expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Overexpression is associated with several cancers including breast cancer and colon tumors.
This product has been referenced in:
Li WF et al. WISP-1 contributes to fractionated irradiation-induced radioresistance in esophageal carcinoma cell lines and mice. PLoS One9:e94751 (2014).
Read more (PubMed: 24728101) »