Recombinant人WHSC2 protein (ab116197)

概述

  • 产品名称
    Recombinant人WHSC2 protein
  • 蛋白长度
    Full length protein

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHHSSGLVPRGSHMPGQRRALSPKMASMRESDTGLWLHNKLGA TDELWAPPSIASLLTAAVIDNIRLCFHGLSSAVKLKLLLGTLHLPRRTVD EMKGALMEIIQLASLDSDPWVLMVADILKSFPDTGSLNLELEEQNPNVQD ILGELREKVGECEASAMLPLECQYLNKNALTTLAGPLTPPVKHFQLKRKP KSATLRAELLQKSTETAQQLKRSAGVPFHAKGRGLLRKMDTTTPLKGIPK QAPFRSPTAPSVFSPTGNRTPIPPSRTLLRKERGVKLLDISELDMVGAGR EAKRRRKTLDAEVVEKPAKEETVVENATPDYAAGLVSTQKLGSLNNEPAL PSTSYLPSTPSVVPASSYIPSSETPPAPSSREASRPPEEPSAPSPTLPAQ FKQRAPMYNSGLSPATPTPAAPTSPLTPTTPPAVAPTTQTPPVAMVAPQT QAPAQQQPKKNLSLTREQMFAAQEMFKTANKVTRPEKALILGFMAGSREN PCQEQGDVIQIKLSEHTEDLPKADGQGSTTMLVDTVFEMNYATGQWTRFK KYKPMTNVS
    • 分子量
      61 kDa including tags
    • 氨基酸
      1 to 539
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab116197 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度
    > 85 % SDS-PAGE.
    ab116197 was purified using conventional chromatography techniques.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 1.17% Sodium chloride, 0.08% DTT, 0.03% EDTA, 20% Glycerol

常规信息

  • 别名
    • FLJ10442
    • FLJ25112
    • Negative elongation factor A
    • Negative elongation factor polypeptide A
    • NELF A
    • NELF-A
    • NELFA
    • NELFA_HUMAN
    • P/OKcl.15
    • P/OKcl15
    • WHSC 2
    • Whsc2
    • Wolf Hirschhorn syndrome candidate 2
    • Wolf Hirschhorn syndrome candidate 2 protein
    • Wolf-Hirschhorn syndrome candidate 2 protein
    see all
  • 功能
    Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Probably required to interact with the RNA polymerase II complex.
  • 组织特异性
    Ubiquitous. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Expressed at lower level in adult lung. Expressed in fetal brain, lung, liver and kidney.
  • 序列相似性
    Belongs to the NELF-A family.
    Contains 1 HDAg-like domain.
  • 结构域
    The HDAg-like domain is essential for transcriptional repression, and mediates the interaction with the RNA polymerase II complex.
  • 细胞定位
    Nucleus.
  • Information by UniProt

图片

  • 15% SDS-PAGE analysis of 3 µg ab116197.

文献

ab116197 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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