Recombinant人VRK1 protein (ab94032)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 序列GYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPG EIA KYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVE NGGLKAKT ITKKRKKEIEESKEPGVEDTEWSNTQTEEAIQTRSRTRKR VQK
    • 氨基酸248 to 396

技术指标

Our Abpromise guarantee covers the use of ab94032 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 形式Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5

  • 复溶Reconstitute with 82 µl aqua dest.

常规信息

  • 别名
    • MGC117401
    • MGC138280
    • MGC142070
    • PCH1
    • PCH1A
    • Serine/threonine protein kinase VRK1
    • Serine/threonine-protein kinase VRK1
    • Vaccinia related kinase 1
    • Vaccinia virus B1R related kinase 1
    • Vaccinia-related kinase 1
    • VRK1
    • VRK1_HUMAN
    see all
  • 功能Serine/threonine kinase that phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2.
  • 组织特异性Widely expressed. Highly expressed in fetal liver, testis and thymus.
  • 疾病相关Defects in VRK1 are the cause of pontocerebellar hypoplasia type 1 (PCH1) [MIM:607596]; also called pontocerebellar hypoplasia with infantile spinal muscular atrophy or pontocerebellar hypoplasia with anterior horn cell disease. PCH1 is characterized by an abnormally small cerebellum and brainstem, central and peripheral motor dysfunction from birth, gliosis and anterior horn cell degeneration resembling infantile spinal muscular atrophy (SMA).
  • 序列相似性Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
    Contains 1 protein kinase domain.
  • 翻译后修饰Autophosphorylated at various serine and threonine residues. Autophosphorylation does not impair its ability to phosphorylate p53/TP53.
  • 细胞定位Nucleus. Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.
  • Information by UniProt

Recombinant Human VRK1 protein 图像

  • The image shows an electrophoretic assay performed using an Agilent 5100 ALP. In some images colored control bands can be seen at 15 kDa (green) and/or 240 kDa (purple). The protein-specific band is blue.

Recombinant Human VRK1 protein (ab94032)参考文献

ab94032 has not yet been referenced specifically in any publications.

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