Recombinant人VEGFD protein (ab125747)

概述

描述

  • 性质
    Recombinant
  • 来源
    HEK 293 cells
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 分子量
      12 kDa
    • 氨基酸
      93 to 201
    • 标签
      His tag C-Terminus

技术指标

Our Abpromise guarantee covers the use of ab125747 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    The ED50 of 3-4ng/ml is measured by its ability to stimulate the proliferation of Human microvascular endothelial cells (HMVECs).
  • 应用

    Functional Studies

    SDS-PAGE

  • 纯度
    > 95 % SDS-PAGE.
    ab125747 was lyophilized after extensive dialysis against PBS.
  • 形式
    Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.

    Constituent: 99% PBS

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 复溶
    It is recommended to reconstitute the ab125747 in sterile ultra pure water not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. Upon reconstitution ab125747 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

常规信息

  • 别名
    • c-fos induced growth factor
    • c-fos induced growth factor (vascular endothelial growth factor D)
    • c-fos-induced growth factor
    • FIGF
    • Vascular endothelial growth factor D
    • Vascular endothelial growth factor D precursor
    • VEGF D
    • VEGF-D
    • VEGFD
    • VEGFD_HUMAN
    see all
  • 功能
    Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
  • 组织特异性
    Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas.
  • 序列相似性
    Belongs to the PDGF/VEGF growth factor family.
  • 翻译后修饰
    Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
  • 细胞定位
    Secreted.
  • Information by UniProt

文献

ab125747 has not yet been referenced specifically in any publications.

客户评价及客户问答

Unfortunately, we have not tested this product's ability to induce phosphorylation of VEGFR2 and so we do not know whether it is capable of doing so.

We have only tested it's ability to stimulate the proliferation of Human microvascular endot...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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