Recombinant人URP2 protein (ab112425)

概述

  • 产品名称Recombinant人URP2 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ86UX7-2
    • 种属Human
    • 序列MAGMKTASGDYIDSSWELRVFVGEEDPEAESVTLRVTGESHIGGVLLKIV EQINRKQDWSDHAIWWEQKRQWLLQTHWTLDKYGILADARLFFGPQHRPV ILRLPNRRALRLRASFSQPLFQAVAAICRLLSIRHPEELSLLRAPEKKEK KKKEKEPEEELYDLSKVVLAGGVAPALFRGMPAHFSDSAQTEACYHMLSR PQPPPDPLLLQRLPRPSSLSDKTQLHSRWLDSSRCLMQQGIKAGDALWLR FKYYSFFDLDPKTDPVRLTQLYEQARWDLLLEEIDCTEEEMMVFAALQYH INKLSQSGEVGEPAGTDPGLDDLDVALSNLEVKLEGSAPTDVLDSLTTIP ELKDHLRIFRPRKLTLKGYRQHWVVFKETTLSYYKSQDEAPGDPIQQLNL KGCEVVPDVNVSGQKFCIKLLVPSPEGMSEIYLRCQDEQQYARWMAGCRL ASKGRTMADSSYTSEVQAILAFLSLQRTGSGGPGNHPHGPDASAEGLNPY GLVAPRFQRKFKAKQLTPRILEAHQNVAQLSLAEAQLRFIQAWQSLPDFG ISYVMVRFKGSRKDEILGIANNRLIRIDLAVGDVVKTWRFSNMRQWNVNW DIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRERARGEELDE DLFLQLTGGHEAF
    • 分子量99 kDa including tags
    • 氨基酸1 to 663

技术指标

Our Abpromise guarantee covers the use of ab112425 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    ELISA

    Western blot

  • 形式Liquid
  • 补充说明Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione

常规信息

  • 别名
    • Fermitin family homolog 3
    • Fermitin family member 3
    • FERMT3
    • Kind3
    • Kindlin 3
    • Kindlin-3
    • Kindlin3
    • MGC10966
    • MIG 2
    • MIG2 like protein
    • MIG2-like protein
    • MIG2B
    • Unc 112 related protein 2
    • Unc-112-related protein 2
    • UNC112C
    • URP2_HUMAN
    • URP2SF
    see all
  • 功能Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs).
    Isoform 2 may act as a repressor of NF-kappa-B and apoptosis.
  • 组织特异性Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.
  • 疾病相关Defects in FERMT3 are the cause of leukocyte adhesion deficiency type 3 (LAD3) [MIM:612840]; also called leukocyte adhesion deficiency 1 variant (LAD1v). LAD3 is a rare syndrome characterized by infections without pus formation in the presence of a leukocytosis combined with a Glanzmann-type bleeding disorder, resulting from a hematopoietic defect in integrin activation. Symptoms arise from an inability to activate the integrins expressed on hematopoietic cells, including platelets and leukocytes.
  • 序列相似性Belongs to the kindlin family.
    Contains 1 FERM domain.
    Contains 1 PH domain.
  • 结构域The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.
  • 细胞定位Cell projection > podosome. Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells.
  • Information by UniProt

Recombinant Human URP2 protein 图像

  • ab112425 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human URP2 protein (ab112425)参考文献

ab112425 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab112425.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"